Localization of immunoreactive thyrotropin releasing hormone in the lower brainstem of the rat

R. L. Eskay, R. T. Long, M. Palkóvits

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The distribution of thyrotropin releasing hormone (TRH) in individual nuclei of the rat brainstem was examined by radioimmunoassay. TRH was detectable in 36 of 40 brainstem nuclei investigated and the localization of TRH in the brainstem was unlike other known brainstem neuropeptides. By far the highest concentration of TRH in the brainstem (1.2 ng/mg protein) is present in the nucleus of the solitary tract. The concentration of TRH was relatively high in the motor nuclei of the IIIrd, Vth, VIIth, Xth and XIIth cranial nerves, and less high in the area postrema, nucleus gracilis, locus coeruleus, lateral reticular nucleus (A1-catecholamine cell group), dorsal raphe and central gray matter. Cerebellum and pontine nuclei contained very low levels (

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalBrain Research
Volume277
Issue number1
DOIs
Publication statusPublished - Oct 24 1983

Fingerprint

Thyrotropin-Releasing Hormone
Brain Stem
Area Postrema
Solitary Nucleus
Locus Coeruleus
Cranial Nerves
Neuropeptides
Cerebellum
Catecholamines
Radioimmunoassay
Proteins

Keywords

  • brainstem
  • radioimmunoassay
  • thyrotropin-releasing hormone

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Localization of immunoreactive thyrotropin releasing hormone in the lower brainstem of the rat. / Eskay, R. L.; Long, R. T.; Palkóvits, M.

In: Brain Research, Vol. 277, No. 1, 24.10.1983, p. 159-162.

Research output: Contribution to journalArticle

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