Localization of acetylcholinesterase in the guinea pig cerebellar cortex

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Abstract

When using the acetylthiocholine method of Koelle and Gerebtzoff for the histochemical localization of acetylcholinesterase, a great variety of synapses within the cerebellar cortex of the guinea pig exhibit enzyme activity. A positive reaction was found in the cerebellar glomeruli of the granular layer, comprising both mossy and Golgi endings. Similar activity is present in the molecular layer, confined to parallel axons. A very strong enzyme reaction was found in the basket synapses around and below Purkinje cell bodies. The obviously presynaptic localization of acetylcholinesterase, and its presence in both excitatory and inhibitory synapses suggest that acetylcholine in these junctions plays the role of a pre-transmitter or modulator substance, promoting the activity of the very excitatory and inhibitory chemical transmitters.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalActa Neurovegetativa
Volume29
Issue number3
DOIs
Publication statusPublished - Sep 1967

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Cerebellar Cortex
Acetylcholinesterase
Synapses
Guinea Pigs
Acetylthiocholine
Purkinje Cells
Enzymes
Acetylcholine
Axons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Localization of acetylcholinesterase in the guinea pig cerebellar cortex. / Csillik, B.; Kása, P.

In: Acta Neurovegetativa, Vol. 29, No. 3, 09.1967, p. 289-296.

Research output: Contribution to journalArticle

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