Local potential connectivity in cat primary visual cortex

Armen Stepanyants, Judith A. Hirsch, Luis M. Martinez, Z. Kisvárday, Alex S. Ferecskó, Dmitri B. Chklovskii

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Time invariant description of synaptic connectivity in cortical circuits may be precluded by the ongoing growth and retraction of dendritic spines accompanied by the formation and elimination of synapses. On the other hand, the spatial arrangement of axonal and dendritic branches appears stable. This suggests that an invariant description of connectivity can be cast in terms of potential synapses, which are locations in the neuropil where an axon branch of one neuron is proximal to a dendritic branch of another neuron. In this paper, we attempt to reconstruct the potential connectivity in local cortical circuits of the cat primary visual cortex (V1). Based on multiple single-neuron reconstructions of axonal and dendritic arbors in 3 dimensions, we evaluate the expected number of potential synapses and the probability of potential connectivity among excitatory (pyramidal and spiny stellate) neurons and inhibitory basket cells. The results provide a quantitative description of structural organization of local cortical circuits. For excitatory neurons from different cortical layers, we compute local domains, which contain their potentially pre- and postsynaptic excitatory partners. These domains have columnar shapes with laminar specific radii and are roughly of the size of the ocular dominance column. Therefore, connections between most excitatory neurons in the ocular dominance column can be implemented by local synaptogenesis. Structural connectivity involving inhibitory basket cells is generally weaker than excitatory connectivity. Here, only nearby neurons are capable of establishing more than one potential synapse, implying that within the ocular dominance column these connections have more limited potential for circuit remodeling.

Original languageEnglish
Pages (from-to)13-28
Number of pages16
JournalCerebral Cortex
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 2008

Fingerprint

Visual Cortex
Cats
Neurons
ocular Dominance
Synapses
Dendritic Spines
Neuropil
Axons
Growth

Keywords

  • Excitatory
  • Inhibitory
  • Interlaminar connectivity
  • Morphology
  • Neurogeometry

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Stepanyants, A., Hirsch, J. A., Martinez, L. M., Kisvárday, Z., Ferecskó, A. S., & Chklovskii, D. B. (2008). Local potential connectivity in cat primary visual cortex. Cerebral Cortex, 18(1), 13-28. https://doi.org/10.1093/cercor/bhm027

Local potential connectivity in cat primary visual cortex. / Stepanyants, Armen; Hirsch, Judith A.; Martinez, Luis M.; Kisvárday, Z.; Ferecskó, Alex S.; Chklovskii, Dmitri B.

In: Cerebral Cortex, Vol. 18, No. 1, 01.2008, p. 13-28.

Research output: Contribution to journalArticle

Stepanyants, A, Hirsch, JA, Martinez, LM, Kisvárday, Z, Ferecskó, AS & Chklovskii, DB 2008, 'Local potential connectivity in cat primary visual cortex', Cerebral Cortex, vol. 18, no. 1, pp. 13-28. https://doi.org/10.1093/cercor/bhm027
Stepanyants A, Hirsch JA, Martinez LM, Kisvárday Z, Ferecskó AS, Chklovskii DB. Local potential connectivity in cat primary visual cortex. Cerebral Cortex. 2008 Jan;18(1):13-28. https://doi.org/10.1093/cercor/bhm027
Stepanyants, Armen ; Hirsch, Judith A. ; Martinez, Luis M. ; Kisvárday, Z. ; Ferecskó, Alex S. ; Chklovskii, Dmitri B. / Local potential connectivity in cat primary visual cortex. In: Cerebral Cortex. 2008 ; Vol. 18, No. 1. pp. 13-28.
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