Local perfusion of the thalamus with GABA increases sleep and induces long-lasting inhibition of somatosensory event-related potentials in cats

G. Juhász, Z. Emri, K. Kékesi, Katalin Pungor

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The extracellular concentration of γ-aminobutyric acid (GABA) was increased in the ventroposterolateral nucleus of the thalamus in cats using in vivo microdialysis probes. In freely moving cats, the permanent injection of 8 × 10-9 M/mm2 × min GABA induced a significant increase in sleep proportion. The duration of paradoxical sleep was particularly increased resembling the effects of benzodiazepines. In chloralose anesthesia, a similar increase in GABA concentration in the thalamus induced a tonic decrease in the peak-to-peak amplitude of cortical event-related potentials evoked by stimulation of the radial nerve. Following 10-15 min of inhibition during which the responses were as small as 20% of the original ones, the potentials started to recover. Finally, the responses were stabilized at a reduced amplitude. The present data suggests the important role of the thalamic GABAergic neurons in the regulation of sleep.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalNeuroscience Letters
Volume103
Issue number2
DOIs
Publication statusPublished - Aug 28 1989

Fingerprint

Thalamus
Evoked Potentials
gamma-Aminobutyric Acid
Sleep
Cats
Perfusion
Aminobutyrates
Radial Nerve
GABAergic Neurons
Chloralose
REM Sleep
Microdialysis
Benzodiazepines
Anesthesia
Injections
Inhibition (Psychology)

Keywords

  • Microdialysis
  • Sleep
  • Thalamus
  • Transmission
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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abstract = "The extracellular concentration of γ-aminobutyric acid (GABA) was increased in the ventroposterolateral nucleus of the thalamus in cats using in vivo microdialysis probes. In freely moving cats, the permanent injection of 8 × 10-9 M/mm2 × min GABA induced a significant increase in sleep proportion. The duration of paradoxical sleep was particularly increased resembling the effects of benzodiazepines. In chloralose anesthesia, a similar increase in GABA concentration in the thalamus induced a tonic decrease in the peak-to-peak amplitude of cortical event-related potentials evoked by stimulation of the radial nerve. Following 10-15 min of inhibition during which the responses were as small as 20{\%} of the original ones, the potentials started to recover. Finally, the responses were stabilized at a reduced amplitude. The present data suggests the important role of the thalamic GABAergic neurons in the regulation of sleep.",
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AU - Juhász, G.

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AU - Kékesi, K.

AU - Pungor, Katalin

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