Local particle deposition patterns may play a key role in the development of lung cancer

Imre Balásházy, Werner Hofmann, Thomas Heistracher

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

The apparent discrepancy between the reported preferential occurrence of bronchial carcinomas in central bronchial airways and current dose estimates for inhaled particles suggests that experimentally observed local accumulations of particles within bronchial airway bifurcations may play a crucial role in lung cancer induction. Here, we computed three-dimensional particle deposition patterns in lobar-segmental airway bifurcations and quantified the resulting inhomogeneous deposition patterns in terms of deposition enhancement factors, which are defined as the ratio of local to average deposition densities. Our results revealed that a small fraction of epithelial cells located at carinal ridges can receive massive doses that may be even a few hundred times higher than the average dose for the whole airway. This lends further credence to the hypothesis that the apparent site selectivity of neoplastic lesions may indeed be caused by the enhanced deposition of toxic particulate matter at bronchial airway bifurcations.

Original languageEnglish
Pages (from-to)1719-1725
Number of pages7
JournalJournal of Applied Physiology
Volume94
Issue number5
DOIs
Publication statusPublished - May 1 2003

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Keywords

  • Deposition distributions
  • Health effects
  • Inhaled particles

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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