Local intracoronary infusions of bradykinin profoundly reduce the severity of ischaemia‐induced arrhythmias in anaesthetized dogs

Agnes Vegh, Laszlo Szekeres, James R. Parratt

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Bradykinin in a dose (25 ng kg−1min−1) which did not alter coronary flow, or saline, were infused into a small branch of the left anterior descending coronary artery in dogs anaesthetized with chloralose and urethane, for 10 min prior to coronary artery occlusion and throughout the 25 min occlusion period. The degree of inhomogeneity of conduction and epicardial ST‐segment changes were measured in the ischaemic zone with a composite electrode. In control dogs, coronary artery occlusion led to severe arrhythmias with an incidence of ventricular fibrillation of 47% and tachycardia of 80% and with a mean of 528 ± 140 ventricular premature beats. In marked contrast, those dogs administered bradykinin had no ventricular fibrillation or tachycardia and the number of premature beats was significantly less (53 ± 19). ST‐segment changes were also much less in these dogs. These results raise the possibility that bradykinin might contribute to the protective effects of preconditioning and acts as an ‘endogenous myocardial protective substance’. 1991 British Pharmacological Society

Original languageEnglish
Pages (from-to)294-295
Number of pages2
JournalBritish journal of pharmacology
Volume104
Issue number2
DOIs
Publication statusPublished - Oct 1991

Keywords

  • Bradykinin
  • ST‐segment changes
  • arrhythmias
  • myocardial ischaemia
  • preconditioning
  • reperfusion
  • ventricular fibrillation

ASJC Scopus subject areas

  • Pharmacology

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