Local deposition distributions of inhaled radionuclides in the human tracheobronchial tree

I. Balashazy, A. Farkas, W. Hofmann, S. Kurunczi, R. Cherubini, D. T. Goodhead, H. G. Menzel, A. Ottolenghi

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Abstract

There is experimental evidence that bronchogenic carcinomas originate mainly at the carinal ridges of the large central airways, where primary hot spots of deposition have been found. However, current lung dosimetry models do not take into consideration the inhomogeneity of deposition within the airways. In this study, computed local distributions of deposited inhaled radionuclides such as radon progenies in morphologically realistic human airway bifurcation models are analysed for different flow rates and particle sizes. Then, local deposition enhancement factors, defined as the ratio of local to average deposition densities, are computed by scanning along the surface of the bifurcation with pre-specified surface area elements. Computed enhancement factors indicate that cells located at carinal ridges or at the inner sides of the progeny branches may receive localised doses which are two orders of magnitude higher than the average values.

Original languageEnglish
Pages (from-to)469-470
Number of pages2
JournalRadiation protection dosimetry
Volume99
Issue number1-4
Publication statusPublished - Aug 26 2002

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ASJC Scopus subject areas

  • Radiation
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Public Health, Environmental and Occupational Health

Cite this

Balashazy, I., Farkas, A., Hofmann, W., Kurunczi, S., Cherubini, R., Goodhead, D. T., Menzel, H. G., & Ottolenghi, A. (2002). Local deposition distributions of inhaled radionuclides in the human tracheobronchial tree. Radiation protection dosimetry, 99(1-4), 469-470.