Local cerebral blood volume determined by three dimensional reconstruction of radionuclide scan data

D. E. Kuhl, M. Reivich, A. Alavi, I. Nyáry, M. M. Staum

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

A method was developed to determine in man absolute values of local cerebral blood volume (LCBV) localized throughout the brain in 3 dimensions and presented in a cross sectional picture format. Previously, absolute values of LCBV have been determined in vivo by stimulated X ray fluorescence, but these determinations have been limited to one point in the brain at a time. All other previous estimates of LCBV by external emission counting have been contaminated by the significant contribution of blood in the overlying scalp and cranium. In the authors' method, a transverse section scan is made after the injection of 99Tc(m) labeled red blood cells into a peripheral vein. Data processing then gives a point to point estimate of absolute radionuclide concentration analogous to an autoradiograph. After the concentration of blood activity is determined, counting data are converted to a 2 dimensional map of LCBV representing a cross section at a known level of the brain. In a series of 5 baboons, the following equation was obtained for the regression plane that relates LCBV in the center of the brain to arterial carbon dioxide tension [P(a)CO 2] and mean arterial blood pressure (MABP): LCBV = 2.88 + 0.049P(a)CO 2 - 0.013MABP. In patients, LCBV values ranged from 2 to 4 ml/100 g depending on location; higher values corresponded to regions of cerebral cortex. Differences in blood volumes of focal brain lesions were also quantified.

Original languageEnglish
Pages (from-to)610-619
Number of pages10
JournalCirculation Research
Volume36
Issue number5
Publication statusPublished - 1975

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Radioisotopes
Brain
Carbon Monoxide
Arterial Pressure
Papio
Cerebral Blood Volume
Blood Volume
Scalp
Skull
Carbon Dioxide
Cerebral Cortex
Veins
Erythrocytes
Fluorescence
X-Rays
Injections

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Local cerebral blood volume determined by three dimensional reconstruction of radionuclide scan data. / Kuhl, D. E.; Reivich, M.; Alavi, A.; Nyáry, I.; Staum, M. M.

In: Circulation Research, Vol. 36, No. 5, 1975, p. 610-619.

Research output: Contribution to journalArticle

Kuhl, D. E. ; Reivich, M. ; Alavi, A. ; Nyáry, I. ; Staum, M. M. / Local cerebral blood volume determined by three dimensional reconstruction of radionuclide scan data. In: Circulation Research. 1975 ; Vol. 36, No. 5. pp. 610-619.
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