Local blood flow in Walker 256 metastatic brain tumors

Ronald G. Blasberg, William R. Shapiro, P. Molnár, Clifford S. Patlak, Joseph D. Fenstermacher

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Local blood flow (F) in metastatic Walker 256 (WL-256) brain tumors produced by the intracarotid artery injection of WL-256 tumor cells in rats was measured using 14C-odoantipyrine and quantitative autoradiography. Blood flow was variable in the tumors; the overall range was 2 to 222 ml hg-1 min-1 and the maximum range in an individual tumor extended over 150 ml hg-1 min-1. Small tumors had mean blood flows similar to surrounding brain. Medium to large tumors had significantly lower flows; the lowest values were usually measured in necrotic or cystic regions, although low values (less than 20 ml hg-1) were also measured in some viable-appearing tumor regions. Blood flow was significantly reduced in brain adjacent to medium and large but not small tumors. A global depression of brain and tumor blood flow was measured in two animals with hydrocephalus and the largest tumor burden. The blood flow patterns of the WL-256 metastatic tumor model are not uniquely different from other brain tumor models although some individual differences exist.

Original languageEnglish
Pages (from-to)195-204
Number of pages10
JournalJournal of Neuro-Oncology
Volume2
Issue number3
DOIs
Publication statusPublished - Sep 1984

Fingerprint

Brain Neoplasms
Neoplasms
Brain
Hydrocephalus
Tumor Burden
Autoradiography
Individuality
Arteries
Injections

Keywords

  • blood flow
  • iodoantipyrine
  • metastatic brain tumors
  • quantitative autoradiography
  • Walker 256 tumors

ASJC Scopus subject areas

  • Neuroscience(all)
  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

Blasberg, R. G., Shapiro, W. R., Molnár, P., Patlak, C. S., & Fenstermacher, J. D. (1984). Local blood flow in Walker 256 metastatic brain tumors. Journal of Neuro-Oncology, 2(3), 195-204. https://doi.org/10.1007/BF00253271

Local blood flow in Walker 256 metastatic brain tumors. / Blasberg, Ronald G.; Shapiro, William R.; Molnár, P.; Patlak, Clifford S.; Fenstermacher, Joseph D.

In: Journal of Neuro-Oncology, Vol. 2, No. 3, 09.1984, p. 195-204.

Research output: Contribution to journalArticle

Blasberg, RG, Shapiro, WR, Molnár, P, Patlak, CS & Fenstermacher, JD 1984, 'Local blood flow in Walker 256 metastatic brain tumors', Journal of Neuro-Oncology, vol. 2, no. 3, pp. 195-204. https://doi.org/10.1007/BF00253271
Blasberg, Ronald G. ; Shapiro, William R. ; Molnár, P. ; Patlak, Clifford S. ; Fenstermacher, Joseph D. / Local blood flow in Walker 256 metastatic brain tumors. In: Journal of Neuro-Oncology. 1984 ; Vol. 2, No. 3. pp. 195-204.
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