Local and systemic hemorheological effects of cerebral hyper- and hypoperfusion in a porcine model

N. Németh, J. Soukup, M. Menzel, D. Henze, T. Clausen, A. Rieger, C. Holz, A. Scharf, F. Hanisch, I. Furka, I. Mikó

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Using a well defined pig model, we investigated whether cerebral hypertension and hypotension influence hemorheological factors. After surgical preparation and stabilization, periods of hyperventilation, controlled periods of cerebral perfusion pressure increases and decreases were utilized. After each period, blood samples were collected from the cannulated femoral artery and vein, and from the superior sagittal sinus. Erythrocyte deformability, whole blood and plasma viscosity and hematological parameters were determined. Erythrocyte deformability significantly worsened in arterial samples after hypertension and hypotension, and in sinus samples it was impaired after hypotension period. Hematocrit significantly increased in arterial and sinus samples during hypertensive period, accompanied by similar alterations in whole blood viscosity. We conclude that hemodynamic changes caused by hyperventilation, hyper- or hypotension can influence hemorheological factors, and suggest that the rheological alterations can affect local hemodynamic and metabolic conditions.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalClinical Hemorheology and Microcirculation
Volume35
Issue number1-2
Publication statusPublished - 2006

Fingerprint

Hypotension
Swine
Erythrocyte Deformability
Blood Viscosity
Hyperventilation
Hypertension
Cerebrovascular Circulation
Hemodynamics
Superior Sagittal Sinus
Femoral Vein
Femoral Artery
Hematocrit

Keywords

  • Cerebral blood flow
  • Cerebral perfusion
  • Hemorheology
  • Hyperventilation

ASJC Scopus subject areas

  • Hematology
  • Physiology

Cite this

Local and systemic hemorheological effects of cerebral hyper- and hypoperfusion in a porcine model. / Németh, N.; Soukup, J.; Menzel, M.; Henze, D.; Clausen, T.; Rieger, A.; Holz, C.; Scharf, A.; Hanisch, F.; Furka, I.; Mikó, I.

In: Clinical Hemorheology and Microcirculation, Vol. 35, No. 1-2, 2006, p. 59-65.

Research output: Contribution to journalArticle

Németh, N, Soukup, J, Menzel, M, Henze, D, Clausen, T, Rieger, A, Holz, C, Scharf, A, Hanisch, F, Furka, I & Mikó, I 2006, 'Local and systemic hemorheological effects of cerebral hyper- and hypoperfusion in a porcine model', Clinical Hemorheology and Microcirculation, vol. 35, no. 1-2, pp. 59-65.
Németh, N. ; Soukup, J. ; Menzel, M. ; Henze, D. ; Clausen, T. ; Rieger, A. ; Holz, C. ; Scharf, A. ; Hanisch, F. ; Furka, I. ; Mikó, I. / Local and systemic hemorheological effects of cerebral hyper- and hypoperfusion in a porcine model. In: Clinical Hemorheology and Microcirculation. 2006 ; Vol. 35, No. 1-2. pp. 59-65.
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