Lnterleukin-8 induces HLA-DR expression on cultured human keratinocytes via specific receptors

L. Kemény, Anna Sz Kenderessy, Imre Ocsovszky, Günter Michel, Thomas Ruzicka, A. Dobozy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Recent studies suggest that interleukin (IL)-8 exerts a direct influence on several functions such as the chemotaxis or proliferation of human keratinocytes (HK). Since the effects of IL-8 in skin are mediated through specific receptors, we have studied the characteristics of the keratinocyte IL-8 receptor. We could identify specific binding sites for IL-8 in cultured HKs by flow cytometry. Pretreatment of the cells with tumor necrosis factor (TNF)-a or IL-la resulted in a significant increase in IL-8 binding. IL-8 selectively induced expression of HLA-DR antigen, but had no effect on the expression of other cell surface antigens (CDlla, CD18, CD36 and CD54).

Original languageEnglish
Pages (from-to)351-356
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume106
Issue number4
DOIs
Publication statusPublished - 1995

Fingerprint

HLA-DR Antigens
Interleukin-8
Keratinocytes
Interleukin-8 Receptors
Interleukins
Chemotaxis
Surface Antigens
Flow Cytometry
Tumor Necrosis Factor-alpha
Binding Sites
Skin

Keywords

  • Cytokines
  • Interleukin-8
  • Skin immune system

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Lnterleukin-8 induces HLA-DR expression on cultured human keratinocytes via specific receptors. / Kemény, L.; Kenderessy, Anna Sz; Ocsovszky, Imre; Michel, Günter; Ruzicka, Thomas; Dobozy, A.

In: International Archives of Allergy and Immunology, Vol. 106, No. 4, 1995, p. 351-356.

Research output: Contribution to journalArticle

Kemény, L. ; Kenderessy, Anna Sz ; Ocsovszky, Imre ; Michel, Günter ; Ruzicka, Thomas ; Dobozy, A. / Lnterleukin-8 induces HLA-DR expression on cultured human keratinocytes via specific receptors. In: International Archives of Allergy and Immunology. 1995 ; Vol. 106, No. 4. pp. 351-356.
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