Liver-on-a-chip-magnetic nanoparticle bound synthetic metalloporphyrin-catalyzed biomimetic oxidation of a drug in a magnechip reactor

Balázs Decsi, Réka Krammer, Kristóf Hegedus, Ferenc Ender, Benjámin Gyarmati, András Szilágyi, Róbert Totos, Gabriel Katona, Csaba Paizs, György T. Balogh, László Poppe, Diána Balogh-Weiser

Research output: Contribution to journalArticle

Abstract

Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin (FeTPFP) and 5,10,15,20- tetrakis-(4-sulfonatophenyl)iron(II) porphyrin (FeTSPP) via stable covalent or rapid ionic binding on aminopropyl-functionalized magnetic nanoparticles (MNPs-NH2) were developed. These immobilized catalysts could be efficiently applied for the synthesis of new pharmaceutically active derivatives and liver related phase I oxidative major metabolite of an antiarrhythmic drug, amiodarone integrated in a continuous-flow magnetic chip reactor (Magnechip).

Original languageEnglish
Article number668
JournalMicromachines
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 1 2019

Fingerprint

Porphyrins
Biomimetics
Metabolites
Liver
Iron
Nanoparticles
Oxidation
Derivatives
Catalysts

Keywords

  • Biomimetic oxidation
  • Drug metabolism
  • Liver-on-a-chip
  • Microfluidics
  • Organ-on-a-chip

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

Liver-on-a-chip-magnetic nanoparticle bound synthetic metalloporphyrin-catalyzed biomimetic oxidation of a drug in a magnechip reactor. / Decsi, Balázs; Krammer, Réka; Hegedus, Kristóf; Ender, Ferenc; Gyarmati, Benjámin; Szilágyi, András; Totos, Róbert; Katona, Gabriel; Paizs, Csaba; Balogh, György T.; Poppe, László; Balogh-Weiser, Diána.

In: Micromachines, Vol. 10, No. 10, 668, 01.10.2019.

Research output: Contribution to journalArticle

Decsi, B, Krammer, R, Hegedus, K, Ender, F, Gyarmati, B, Szilágyi, A, Totos, R, Katona, G, Paizs, C, Balogh, GT, Poppe, L & Balogh-Weiser, D 2019, 'Liver-on-a-chip-magnetic nanoparticle bound synthetic metalloporphyrin-catalyzed biomimetic oxidation of a drug in a magnechip reactor', Micromachines, vol. 10, no. 10, 668. https://doi.org/10.3390/mi10100668
Decsi, Balázs ; Krammer, Réka ; Hegedus, Kristóf ; Ender, Ferenc ; Gyarmati, Benjámin ; Szilágyi, András ; Totos, Róbert ; Katona, Gabriel ; Paizs, Csaba ; Balogh, György T. ; Poppe, László ; Balogh-Weiser, Diána. / Liver-on-a-chip-magnetic nanoparticle bound synthetic metalloporphyrin-catalyzed biomimetic oxidation of a drug in a magnechip reactor. In: Micromachines. 2019 ; Vol. 10, No. 10.
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