Liver-on-a-chip-magnetic nanoparticle bound synthetic metalloporphyrin-catalyzed biomimetic oxidation of a drug in a magnechip reactor

Balázs Decsi, Réka Krammer, Kristóf Hegedus, Ferenc Ender, Benjámin Gyarmati, András Szilágyi, Róbert Totos, Gabriel Katona, Csaba Paizs, György T. Balogh, László Poppe, Diána Balogh-Weiser

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin (FeTPFP) and 5,10,15,20- tetrakis-(4-sulfonatophenyl)iron(II) porphyrin (FeTSPP) via stable covalent or rapid ionic binding on aminopropyl-functionalized magnetic nanoparticles (MNPs-NH2) were developed. These immobilized catalysts could be efficiently applied for the synthesis of new pharmaceutically active derivatives and liver related phase I oxidative major metabolite of an antiarrhythmic drug, amiodarone integrated in a continuous-flow magnetic chip reactor (Magnechip).

Original languageEnglish
Article number668
JournalMicromachines
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 1 2019

Keywords

  • Biomimetic oxidation
  • Drug metabolism
  • Liver-on-a-chip
  • Microfluidics
  • Organ-on-a-chip

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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  • Cite this

    Decsi, B., Krammer, R., Hegedus, K., Ender, F., Gyarmati, B., Szilágyi, A., Totos, R., Katona, G., Paizs, C., Balogh, G. T., Poppe, L., & Balogh-Weiser, D. (2019). Liver-on-a-chip-magnetic nanoparticle bound synthetic metalloporphyrin-catalyzed biomimetic oxidation of a drug in a magnechip reactor. Micromachines, 10(10), [668]. https://doi.org/10.3390/mi10100668