Liver lipid peroxidation induced by cholesterol and its treatment with a dihydroquinoline type free radical scavenger in rabbits

S. Sulyok, Z. Bar-Pollak, E. Fehér, I. Kemenes, I. Kántor, J. Fehér

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Lipid peroxidation has been induced by means of an atherogenic diet causing hypercholesterolaemia, hypertriglyceridaemia, increased LDL and decreased HDL serum fractions in addition to fatty degeneration, vacuolization of the liver cells and accumulation of malondialdehyde in the liver. Increased release of acid phosphatase and N-beta-glucuronidase was also observed, pointing to cholesterol-induced lysosomal membrane damage. In response to pretreatment with, and simultaneous administration of, 6,6'-methylene bis (2,2-dimethyl-4-methane sulphonic acid sodium salt-1,2-dihydroquinoline) the signs and symptoms of fatty liver degeneration, the tissue, plasma and platelet malondialdehyde concentrations and the LDL serum fraction significantly decreased and HDL serum fraction increased. Lysosomal membrane stability was restored, resulting in physiological acid phosphatase and N-beta-glucuronidase activities. The pathological and clinical aspects of lipid peroxidation in several diseases of the digestive organs and the suggested therapeutic uses of non-toxic radical scavengers have been outlined.

Original languageEnglish
Pages (from-to)437-442
Number of pages6
JournalActa Physiologica Hungarica
Volume64
Issue number3-4
Publication statusPublished - 1984

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Free Radical Scavengers
Lipid Peroxidation
Glucuronidase
Cholesterol
Acid Phosphatase
Rabbits
Malondialdehyde
Liver
Serum
Atherogenic Diet
Membranes
Sulfonic Acids
Hypertriglyceridemia
Methane
Therapeutic Uses
Fatty Liver
Hypercholesterolemia
Signs and Symptoms
Blood Platelets
Salts

ASJC Scopus subject areas

  • Physiology

Cite this

Liver lipid peroxidation induced by cholesterol and its treatment with a dihydroquinoline type free radical scavenger in rabbits. / Sulyok, S.; Bar-Pollak, Z.; Fehér, E.; Kemenes, I.; Kántor, I.; Fehér, J.

In: Acta Physiologica Hungarica, Vol. 64, No. 3-4, 1984, p. 437-442.

Research output: Contribution to journalArticle

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