Liver in sepsis and systemic inflammatory response syndrome

G. Szabó, Laszlo Romics, Gyorgy Frendl

Research output: Contribution to journalReview article

111 Citations (Scopus)

Abstract

In patients with sepsis and SIRS, the liver has two opposing roles: a source of inflammatory mediators and a target organ for the effects of the inflammatory mediators. The liver is pivotal in modulating the systemic response to severe infection, because it contains the largest mass of macrophages (Kupffer cells) in the body; these macrophages can clear the endotoxin and bacteria that initiate the systemic inflammatory response. This article summarizes the functional changes that take place in the liver during sepsis and systemic inflammatory response syndrome and discusses the cellular and molecular mechanisms that underlie clinical outcomes.

Original languageEnglish
Pages (from-to)1045-1066
Number of pages22
JournalClinics in Liver Disease
Volume6
Issue number4
DOIs
Publication statusPublished - Nov 2002

Fingerprint

Systemic Inflammatory Response Syndrome
Sepsis
Liver
Macrophages
Kupffer Cells
Endotoxins
Bacteria
Infection

ASJC Scopus subject areas

  • Hepatology

Cite this

Liver in sepsis and systemic inflammatory response syndrome. / Szabó, G.; Romics, Laszlo; Frendl, Gyorgy.

In: Clinics in Liver Disease, Vol. 6, No. 4, 11.2002, p. 1045-1066.

Research output: Contribution to journalReview article

Szabó, G. ; Romics, Laszlo ; Frendl, Gyorgy. / Liver in sepsis and systemic inflammatory response syndrome. In: Clinics in Liver Disease. 2002 ; Vol. 6, No. 4. pp. 1045-1066.
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