Májfibrosis: Patofiziológia, diagnosztika, terápia

Translated title of the contribution: Liver fibrosis: Pathophysiology, diagnosis and treatment

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The extracellular matrix deposition in the liver parenchyma is a major component of cirrhosis. A great deal of knowledge has been gathered in the past two decades regarding the regulation and dynamics of fibrogenesis, and based on these advances, a review is delivered on the pathophysiology, diagnosis and therapy of liver fibrosis. The key event in fibrogenesis is the activation of hepatic stellate cells, and in its mechanism, inflammation, oxidative stress, steatosis, cytokines, growth factors, enzymes and enzyme inhibitors play a pivotal role. The phenotypic response of activated stellate cells comprises proliferation, fibrogenesis, contractiliy, loss of vitamin A and matrix degradation. In the diagnosis of liver fibrosis, besides liver biopsy - as "golden standard" - recently non-invasive methods, such as imaging techniques, and mainly serum fibrosis markers and indices have widely been studied. Experimental and clinical data have proved the reversibility of fibrosis, and suggested that an effective antifibrotic treatment in the future may serve even for the prevention of cirrhosis.

Original languageHungarian
Pages (from-to)3-13
Number of pages11
JournalOrvosi Hetilap
Volume146
Issue number1
Publication statusPublished - 2005

Fingerprint

Liver Cirrhosis
Fibrosis
Hepatic Stellate Cells
Growth Inhibitors
Liver
Enzyme Inhibitors
Vitamin A
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Oxidative Stress
Biomarkers
Cell Proliferation
Cytokines
Inflammation
Biopsy
Enzymes
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Májfibrosis : Patofiziológia, diagnosztika, terápia. / Pár, A.; Pár, G.

In: Orvosi Hetilap, Vol. 146, No. 1, 2005, p. 3-13.

Research output: Contribution to journalArticle

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