Lithium induces phosphoglucomutase activity in various tissues of rats and in bipolar patients

Péter Csutora, Árpád Karsai, Tamás Nagy, Bálint Vas, Gábor L. Kovács, Orsolya Rideg, Péter Bogner, Attila Miseta

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Phosphoglucomutase catalyses the reversible conversion of glucose-6-P and glucose-1-P. Lithium is a potent inhibitor of phosphoglucomutase in vitro, however, it is not known if phosphoglucomutase was significantly inhibited by Li+ in Li+-treated bipolar patients. Here, we demonstrate that phosphoglucomutase inhibition by chronic Li+ treatment causes alterations of glucose-phosphate levels in various tissues of rats. Also, phosphoglucomutase inhibition results in compensatory elevation of phosphoglucomutase activity in rat tissues and in leukocytes isolated from Li+-treated bipolar patients. The increase of uninhibited phosphoglucomutase activity in leukocytes of Li+-treated bipolar patients is due to the increased expression of the PGM1 gene.

Original languageEnglish
Pages (from-to)613-619
Number of pages7
JournalInternational Journal of Neuropsychopharmacology
Volume9
Issue number5
DOIs
Publication statusPublished - Oct 1 2006

    Fingerprint

Keywords

  • Bipolar disorder
  • Glucose-phosphate
  • Lithium
  • Magnesium
  • Phosphoglucomutase

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this