Liquid-phase Synthesis of Mixture-based Bicyclic β-Lactam Libraries

Szilvia Gedey, Pirjo Vainiotalo, I. Zupkó, Peter A M De Witte, F. Fülöp

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Five sets of 27-membered combinatorial libraries of alicyclic β-lactams were prepared via liquid-phase Ugi 4-center 3-component reactions (U-4C-3CR) utilizing 3 different cis β-amino acids, 3 different isonitriles and 5x3 sets of aldehydes. Through combinations of the building blocks of one of these libraries, all of the possible sublibraries were also generated. A few azetidinone derivatives were synthesized individually by parallel synthesis.

Original languageEnglish
Pages (from-to)951-956
Number of pages6
JournalJournal of Heterocyclic Chemistry
Volume40
Issue number6
Publication statusPublished - Nov 2003

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Lactams
Aldehydes
Derivatives
Amino Acids
Liquids
2-azetidinone

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Liquid-phase Synthesis of Mixture-based Bicyclic β-Lactam Libraries. / Gedey, Szilvia; Vainiotalo, Pirjo; Zupkó, I.; De Witte, Peter A M; Fülöp, F.

In: Journal of Heterocyclic Chemistry, Vol. 40, No. 6, 11.2003, p. 951-956.

Research output: Contribution to journalArticle

Gedey, Szilvia ; Vainiotalo, Pirjo ; Zupkó, I. ; De Witte, Peter A M ; Fülöp, F. / Liquid-phase Synthesis of Mixture-based Bicyclic β-Lactam Libraries. In: Journal of Heterocyclic Chemistry. 2003 ; Vol. 40, No. 6. pp. 951-956.
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