Liquid-Phase Combinatorial Synthesis of Alicyclic β-Lactams via Ugi Four-Component Reaction

Szilvia Gedey, Johan Van Der Eycken, F. Fülöp

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

(Equation Presented) Alicyclic β-lactams were successfully synthesized via a parallel liquid-phase Ugi four-center three-component reaction (U-4C-3CR), starting from alicyclic β-amino acids such as cis-2-aminocyclohexanecarboxylic acid, cis-2-aminocyclopentanecarboxylic acid, 2,3-diexo-3-aminobicyclo-[2.2.1]heptane-2-carboxylic acid and some of their partially unsaturated analogues. A six-membered mixture-based combinatorial library of β-lactams was also generated.

Original languageEnglish
Pages (from-to)1967-1969
Number of pages3
JournalOrganic Letters
Volume4
Issue number11
DOIs
Publication statusPublished - May 30 2002

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Lactams
liquid phases
Cycloleucine
Heptanes
acids
Liquids
synthesis
heptanes
Carboxylic Acids
carboxylic acids
amino acids
analogs
Amino Acids
2-aminocyclohexanecarboxylic acid

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Liquid-Phase Combinatorial Synthesis of Alicyclic β-Lactams via Ugi Four-Component Reaction. / Gedey, Szilvia; Van Der Eycken, Johan; Fülöp, F.

In: Organic Letters, Vol. 4, No. 11, 30.05.2002, p. 1967-1969.

Research output: Contribution to journalArticle

Gedey, Szilvia ; Van Der Eycken, Johan ; Fülöp, F. / Liquid-Phase Combinatorial Synthesis of Alicyclic β-Lactams via Ugi Four-Component Reaction. In: Organic Letters. 2002 ; Vol. 4, No. 11. pp. 1967-1969.
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