Liquid chromatographic-mass spectrometric studies on rifamycin antibiotics

K. Vékey, D. M.F. Edwards, L. F. Zerilli

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The use of a direct liquid introduction type liquid chromatographic-mass spectrometric interface to study highly thermally labile rifamycin antibiotics is described. Using negative ionization, abundant molecular ions were observed, and the spectra also contained structurally significant fragments. Variation of the high- performance liquid chromatographic parameters did not change the spectra, thus making it easy to change chromatographic conditions. In quantitative studies, a surprising correlation was found, indicating that the mass spectrometric signal was proportional to the square of the sample concentration.

Original languageEnglish
Pages (from-to)317-327
Number of pages11
JournalJournal of Chromatography A
Issue number1
Publication statusPublished - Jul 14 1989


ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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