Liposzómák átlagos vezikulaméretének befolyásolása bözacsIra olajjal

Jójártné Laczkovich Orsolya, Bónis Erzsébet, Németh Zsofia, P. Szabó-Révész

Research output: Contribution to journalArticle

Abstract

Introduction: Liposomal formulations are important nano-carTiers of the modern pharmaceutical technology. The reason of the central position of this form is their role in active and passive target therapy. Designing the vesicle sizes is crucial for the application. Aim: This publication gives a short literature background about the topic of liposomal preparations, and focuses on the mean yeside size. The aim of the experimental part is the investigation of the vesicle sizes. The work deals with application of wheat germ oil as wall component and its impact on mean vesicle size and size distribution. Method: One of the investigation methods was dynamic light scattering process. Additionally, thermomicroscopy, differential scanning calorimetry and X-ray powder dffraction (XRPD) were applied. Results: The lipid film hydration method resulted in smooth thin film layer and the mean vesicle size of liposomes was smaller than 200 nm. The amount of wheat germ oil using as a wall additive influenced on the vesicle size. 5 wlu% wheat germ oil resulted in the most effective vesicle size reduction. This concentration is the optimal for the fluidity of the phospholipid layer. Using higher amount of oil increased the polydispersity of the product. 20 w/w% oil content affected adversely the product's properties. XRPD measurement showed that product stabilization could be reached with lyophilization for two days in the presence of trehalose as cryoprotectant agent. Conclusion: Based on the results, it can be concluded that the phase transition temperature of the wall components can be measured with thermoanalytical techniques and the results can be used for setting the preparation parameters. Furthermore, using 5 w/w% wheat germ oil could be suggested to decrease the vesicle size.

Original languageHungarian
Pages (from-to)9-16
Number of pages8
JournalActa Pharmaceutica Hungarica
Volume88
Issue number1
Publication statusPublished - Jan 1 2018

ASJC Scopus subject areas

  • Pharmaceutical Science

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