Liposomes from soya phospholipids as percutaneous drug carriers. 2nd Communication: Quantitative in vivo investigations with radioactively labelled liposomes

C. Artmann, J. Roding, M. Ghyczy, H. G. Pratzel

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The percutaneous absorption of liposomes (prepared from NAT 106) was investigated with radioactively labelled substances in comparison with percutaneous absorption without liposomes (controls) in vivo on the skin of young pigs. Radioactivity was monitored as a function of time in skin tissue, plasma or blood and in urine. Elevated tissue levels, increased absorption and renal elimination of the various liposomal preparations in comparison to the controls were measured.

Original languageEnglish
Pages (from-to)1365-1368
Number of pages4
JournalArzneimittel-Forschung/Drug Research
Volume40
Issue number12
Publication statusPublished - Dec 1 1990

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Keywords

  • drug carriers, percutaneous
  • heparin
  • liposomes, absorption, penetration
  • phosphatidylcholine
  • sodium pertechnate

ASJC Scopus subject areas

  • Drug Discovery

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