Liposomes

Bio-inspired nano-containers for physically triggered targeted drug delivery

Sofiya Matviykiv, Marzia Buscema, T. Mészáros, Gabriela Gerganova, Thomas Pfohl, Andreas Zumbühl, J. Szebeni, Bert Müller

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

For natural scientists and engineers, learning from nature has tradition and is often driven by bio-inspired processes and materials. For example, engineers have designed multifunctional materials with hierarchical structures. Lipid bilayers, the principal components of cell membranes, can form vesicles, termed liposomes. Such liposomes are usually recognized as foreign by the immune system of a patient, which makes it challenging to use liposomes as containers for targeted drug delivery. There are, however, promising non-spherical, mechano-sensitive, artificial liposomes about 100 nm in diameter, which were recently identified. These bio-inspired containers offer a wide range of applications. In particular, the targeted release at critically stenosed arteries formed as a result of atherosclerosis significantly reduces the undesired side effects such as a drop of blood pressure. It is well known that FDA-approved liposomal drugs, currently on the market, often induce adverse immune responses. Therefore, to exclude the hypersensitivity of the recently discovered mechano-sensitive liposomes, we have performed in vitro complement activation experiments and related animal studies with pigs. Recently, it has been shown that the drug-free Pad-PC-Pad liposomes surprisingly lack any complement activation. In this study, we demonstrate that nitroglycerin-loaded liposomes with relevant human therapeutic dosage exhibit low complement activation compared to the FDA-approved phospholipid drugs, including Abelcet. Furthermore, the liposomal suspensions applied are stable for a period of more than two months. Consequently, the non-spherical liposomes of nanometer size we have developed are promising containers for physically triggered, targeted drug delivery.

Original languageEnglish
Title of host publicationBioinspiration, Biomimetics, and Bioreplication 2017
PublisherSPIE
Volume10162
ISBN (Electronic)9781510608092
DOIs
Publication statusPublished - Jan 1 2017
EventBioinspiration, Biomimetics, and Bioreplication 2017 - Portland, United States
Duration: Mar 26 2017Mar 27 2017

Other

OtherBioinspiration, Biomimetics, and Bioreplication 2017
CountryUnited States
CityPortland
Period3/26/173/27/17

Fingerprint

Liposomes
Drug Delivery
Container
containers
Containers
delivery
drugs
complement
activation
engineers
Activation
nitroglycerin
Drugs
Complement
Chemical activation
arteriosclerosis
immune systems
blood pressure
swine
arteries

Keywords

  • atherosclerosis
  • biomimetic
  • complement activation
  • hypersensitivity
  • liposome
  • Nanotechnology
  • shear stress
  • targeted drug delivery

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Matviykiv, S., Buscema, M., Mészáros, T., Gerganova, G., Pfohl, T., Zumbühl, A., ... Müller, B. (2017). Liposomes: Bio-inspired nano-containers for physically triggered targeted drug delivery. In Bioinspiration, Biomimetics, and Bioreplication 2017 (Vol. 10162). [101620A] SPIE. https://doi.org/10.1117/12.2258378

Liposomes : Bio-inspired nano-containers for physically triggered targeted drug delivery. / Matviykiv, Sofiya; Buscema, Marzia; Mészáros, T.; Gerganova, Gabriela; Pfohl, Thomas; Zumbühl, Andreas; Szebeni, J.; Müller, Bert.

Bioinspiration, Biomimetics, and Bioreplication 2017. Vol. 10162 SPIE, 2017. 101620A.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Matviykiv, S, Buscema, M, Mészáros, T, Gerganova, G, Pfohl, T, Zumbühl, A, Szebeni, J & Müller, B 2017, Liposomes: Bio-inspired nano-containers for physically triggered targeted drug delivery. in Bioinspiration, Biomimetics, and Bioreplication 2017. vol. 10162, 101620A, SPIE, Bioinspiration, Biomimetics, and Bioreplication 2017, Portland, United States, 3/26/17. https://doi.org/10.1117/12.2258378
Matviykiv S, Buscema M, Mészáros T, Gerganova G, Pfohl T, Zumbühl A et al. Liposomes: Bio-inspired nano-containers for physically triggered targeted drug delivery. In Bioinspiration, Biomimetics, and Bioreplication 2017. Vol. 10162. SPIE. 2017. 101620A https://doi.org/10.1117/12.2258378
Matviykiv, Sofiya ; Buscema, Marzia ; Mészáros, T. ; Gerganova, Gabriela ; Pfohl, Thomas ; Zumbühl, Andreas ; Szebeni, J. ; Müller, Bert. / Liposomes : Bio-inspired nano-containers for physically triggered targeted drug delivery. Bioinspiration, Biomimetics, and Bioreplication 2017. Vol. 10162 SPIE, 2017.
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