Liposome triggering of innate immune responses: A perspective on benefits and adverse reactions

Janos Szebeni, Seyed Moein Moghimi

Research output: Contribution to journalComment/debate

56 Citations (Scopus)

Abstract

This commentary focuses on therapeutic advantages as well as adverse reactions that entail liposome triggering of the innate immune system, notably the complement cascade and macrophage clearance mechanisms. Our discussion is centered on macrophage drug delivery, evasion of macrophage surveillance, immunogenicity, and hypersensitivity.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalJournal of Liposome Research
Volume19
Issue number2
DOIs
Publication statusPublished - Jan 1 2009

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Keywords

  • Complement inhibitor
  • Complement system
  • Drug delivery
  • Hypersensitivity
  • Immunogenicity
  • Liposome
  • Macrophage

ASJC Scopus subject areas

  • Pharmaceutical Science

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