Liposomal hydrogels and soft contact lenses for the delivery of antibiotics in ophthalmology

M. Budai, Mária Hajdú, Lívia Budai, I. Antal, Katalin Lenti, I. Klebovich

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pharmacotechnological developments aim to increase the safety, efficacy and bioavailability of ophthalmic products, meanwhile paying attention to formulate complex drug carrier systems. In order to overcome the problem of chemical instability of antibiotics and ensure controlled drug release liposomal encapsulation of the ophthalmic drugs was carried out. For an improved ophthalmic bioavailability and lengthened therapeutic action drug vehicle systems possessing enhanced viscosity are required. Optimal formulations based on multilamellar liposomes incorporated into hydrogels or contact lenses prepared from hydrogels may fulfill the criterion of optimal ophthalmic systems. As antibiotics oxytetracycline or ciprofloxacin were incorporated into the gels/ soft contact lenses. Multilamellar vesicles were produced from lecithin or α-L-dipalmithoylphosphatidylcholine with thin-film hydration technique. Hydrogels prepared from poly(vinyl alcohol), polymethacrylic acid derivatives or from cellulose derivatives in a concentration of 0.1 - 15.0 w/w % were applied to test the physicochemical parameters of the proposed complex therapeutic systems. Viscometry and extensometry were used to measure the physical parameters of the formulations. Furthermore, in vitro drug release tests were performed to predict and compare the in vivo fate of antibiotics incorporated into liposomal gels. Study results confirm that biocompatible polymers are suitable as active ingredient carriers for developing complex drug delivery systems. Liposomal encapsulation may further improve the pharmacokinetic parameters related to encapsulation efficiency and lipid composition.

Original languageEnglish
Title of host publicationHandbook of Hydrogels: Properties, Preparation & Applications
PublisherNova Science Publishers, Inc.
Pages663-673
Number of pages11
ISBN (Print)9781607417026
Publication statusPublished - Jan 2011

Fingerprint

contact lenses
ophthalmology
antibiotics
delivery
drugs
bioavailability
gels
viscometry
formulations
wireless communication
cellulose
ingredients
hydration
lipids
safety
vehicles
alcohols
lenses
viscosity
acids

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Budai, M., Hajdú, M., Budai, L., Antal, I., Lenti, K., & Klebovich, I. (2011). Liposomal hydrogels and soft contact lenses for the delivery of antibiotics in ophthalmology. In Handbook of Hydrogels: Properties, Preparation & Applications (pp. 663-673). Nova Science Publishers, Inc..

Liposomal hydrogels and soft contact lenses for the delivery of antibiotics in ophthalmology. / Budai, M.; Hajdú, Mária; Budai, Lívia; Antal, I.; Lenti, Katalin; Klebovich, I.

Handbook of Hydrogels: Properties, Preparation & Applications. Nova Science Publishers, Inc., 2011. p. 663-673.

Research output: Chapter in Book/Report/Conference proceedingChapter

Budai, M, Hajdú, M, Budai, L, Antal, I, Lenti, K & Klebovich, I 2011, Liposomal hydrogels and soft contact lenses for the delivery of antibiotics in ophthalmology. in Handbook of Hydrogels: Properties, Preparation & Applications. Nova Science Publishers, Inc., pp. 663-673.
Budai M, Hajdú M, Budai L, Antal I, Lenti K, Klebovich I. Liposomal hydrogels and soft contact lenses for the delivery of antibiotics in ophthalmology. In Handbook of Hydrogels: Properties, Preparation & Applications. Nova Science Publishers, Inc. 2011. p. 663-673
Budai, M. ; Hajdú, Mária ; Budai, Lívia ; Antal, I. ; Lenti, Katalin ; Klebovich, I. / Liposomal hydrogels and soft contact lenses for the delivery of antibiotics in ophthalmology. Handbook of Hydrogels: Properties, Preparation & Applications. Nova Science Publishers, Inc., 2011. pp. 663-673
@inbook{664da35d2773456b86a2548cd26b83d2,
title = "Liposomal hydrogels and soft contact lenses for the delivery of antibiotics in ophthalmology",
abstract = "Pharmacotechnological developments aim to increase the safety, efficacy and bioavailability of ophthalmic products, meanwhile paying attention to formulate complex drug carrier systems. In order to overcome the problem of chemical instability of antibiotics and ensure controlled drug release liposomal encapsulation of the ophthalmic drugs was carried out. For an improved ophthalmic bioavailability and lengthened therapeutic action drug vehicle systems possessing enhanced viscosity are required. Optimal formulations based on multilamellar liposomes incorporated into hydrogels or contact lenses prepared from hydrogels may fulfill the criterion of optimal ophthalmic systems. As antibiotics oxytetracycline or ciprofloxacin were incorporated into the gels/ soft contact lenses. Multilamellar vesicles were produced from lecithin or α-L-dipalmithoylphosphatidylcholine with thin-film hydration technique. Hydrogels prepared from poly(vinyl alcohol), polymethacrylic acid derivatives or from cellulose derivatives in a concentration of 0.1 - 15.0 w/w {\%} were applied to test the physicochemical parameters of the proposed complex therapeutic systems. Viscometry and extensometry were used to measure the physical parameters of the formulations. Furthermore, in vitro drug release tests were performed to predict and compare the in vivo fate of antibiotics incorporated into liposomal gels. Study results confirm that biocompatible polymers are suitable as active ingredient carriers for developing complex drug delivery systems. Liposomal encapsulation may further improve the pharmacokinetic parameters related to encapsulation efficiency and lipid composition.",
author = "M. Budai and M{\'a}ria Hajd{\'u} and L{\'i}via Budai and I. Antal and Katalin Lenti and I. Klebovich",
year = "2011",
month = "1",
language = "English",
isbn = "9781607417026",
pages = "663--673",
booktitle = "Handbook of Hydrogels: Properties, Preparation & Applications",
publisher = "Nova Science Publishers, Inc.",

}

TY - CHAP

T1 - Liposomal hydrogels and soft contact lenses for the delivery of antibiotics in ophthalmology

AU - Budai, M.

AU - Hajdú, Mária

AU - Budai, Lívia

AU - Antal, I.

AU - Lenti, Katalin

AU - Klebovich, I.

PY - 2011/1

Y1 - 2011/1

N2 - Pharmacotechnological developments aim to increase the safety, efficacy and bioavailability of ophthalmic products, meanwhile paying attention to formulate complex drug carrier systems. In order to overcome the problem of chemical instability of antibiotics and ensure controlled drug release liposomal encapsulation of the ophthalmic drugs was carried out. For an improved ophthalmic bioavailability and lengthened therapeutic action drug vehicle systems possessing enhanced viscosity are required. Optimal formulations based on multilamellar liposomes incorporated into hydrogels or contact lenses prepared from hydrogels may fulfill the criterion of optimal ophthalmic systems. As antibiotics oxytetracycline or ciprofloxacin were incorporated into the gels/ soft contact lenses. Multilamellar vesicles were produced from lecithin or α-L-dipalmithoylphosphatidylcholine with thin-film hydration technique. Hydrogels prepared from poly(vinyl alcohol), polymethacrylic acid derivatives or from cellulose derivatives in a concentration of 0.1 - 15.0 w/w % were applied to test the physicochemical parameters of the proposed complex therapeutic systems. Viscometry and extensometry were used to measure the physical parameters of the formulations. Furthermore, in vitro drug release tests were performed to predict and compare the in vivo fate of antibiotics incorporated into liposomal gels. Study results confirm that biocompatible polymers are suitable as active ingredient carriers for developing complex drug delivery systems. Liposomal encapsulation may further improve the pharmacokinetic parameters related to encapsulation efficiency and lipid composition.

AB - Pharmacotechnological developments aim to increase the safety, efficacy and bioavailability of ophthalmic products, meanwhile paying attention to formulate complex drug carrier systems. In order to overcome the problem of chemical instability of antibiotics and ensure controlled drug release liposomal encapsulation of the ophthalmic drugs was carried out. For an improved ophthalmic bioavailability and lengthened therapeutic action drug vehicle systems possessing enhanced viscosity are required. Optimal formulations based on multilamellar liposomes incorporated into hydrogels or contact lenses prepared from hydrogels may fulfill the criterion of optimal ophthalmic systems. As antibiotics oxytetracycline or ciprofloxacin were incorporated into the gels/ soft contact lenses. Multilamellar vesicles were produced from lecithin or α-L-dipalmithoylphosphatidylcholine with thin-film hydration technique. Hydrogels prepared from poly(vinyl alcohol), polymethacrylic acid derivatives or from cellulose derivatives in a concentration of 0.1 - 15.0 w/w % were applied to test the physicochemical parameters of the proposed complex therapeutic systems. Viscometry and extensometry were used to measure the physical parameters of the formulations. Furthermore, in vitro drug release tests were performed to predict and compare the in vivo fate of antibiotics incorporated into liposomal gels. Study results confirm that biocompatible polymers are suitable as active ingredient carriers for developing complex drug delivery systems. Liposomal encapsulation may further improve the pharmacokinetic parameters related to encapsulation efficiency and lipid composition.

UR - http://www.scopus.com/inward/record.url?scp=84896415956&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896415956&partnerID=8YFLogxK

M3 - Chapter

SN - 9781607417026

SP - 663

EP - 673

BT - Handbook of Hydrogels: Properties, Preparation & Applications

PB - Nova Science Publishers, Inc.

ER -