Lipoproteins, lipid droplets, lysosomes, and adrenocortical steroid hormone synthesis: Morphological studies

I. Tóth, Dezso Szabo, Geza G. Bruckner

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Recent studies concerning cellular cholesterol homeostasis suggest that there is a relationship between the serum lipoproteins (low density and high density lipoproteins: LDL and HDL), the intracellular storage of cholesterol (lipid droplets), lysosomes, and the steroidogenic activity of adrenocortical cells. This review surveys the current knowledge on cholesterol import from LDL/HDL by adrenocortical cells, its regulation, and the participation of lipid droplets and lysosomes in this process. The possible role of adrenocortical cell microvilli in the uptake of LDL/HDL is discussed. Under certain physiological, experimental, and pathological circumstances lysosomes accumulate unesterified and/or esterified cholesterol in the form of lipid- lysosome complexes. As suggested by the data presented in this review, lipid- lysosome complexes appear to be involved in cholesterol homeostasis, via altering lipid compartmentalization. Since previous reports do not clearly demonstrate a positive correlation between the volume of lipid- and lysosome- compartments and the rate of steroid hormone synthesis [for review, see Nussdorfer (1986) Int. Rev. Cytol., 98:1-405], the objective of this review is to provide a better understanding of the interactions of plasma lipoproteins, lipid droplets, lysosomes, and steroidogenesis.

Original languageEnglish
Pages (from-to)480-492
Number of pages13
JournalMicroscopy Research and Technique
Volume36
Issue number6
DOIs
Publication statusPublished - 1997

Fingerprint

Steroid hormones
lipoproteins
lysosomes
Lipoproteins
steroids
hormones
steroid hormones
adrenal cortex hormones
Lysosomes
Lipids
droplets
lipids
Cholesterol
cholesterol
Steroids
Hormones
synthesis
hardware description languages
homeostasis
Homeostasis

Keywords

  • α-MSH
  • ACTH
  • cholesterol crystal
  • colloidal gold
  • LDL receptors
  • LDL/HDL immunoelectron microscopy
  • lipid-lysosome complexes
  • microvilli

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

Cite this

Lipoproteins, lipid droplets, lysosomes, and adrenocortical steroid hormone synthesis : Morphological studies. / Tóth, I.; Szabo, Dezso; Bruckner, Geza G.

In: Microscopy Research and Technique, Vol. 36, No. 6, 1997, p. 480-492.

Research output: Contribution to journalArticle

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