Lipoprotein (a) and plasminogen are immunochemically related

I. Karádi, Gerhard M. Kostner, Anni Gries, Johannes Nimpf, Làszló Romics, Ernst Malle

Research output: Contribution to journalArticle

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Abstract

Earlier studies demonstrated that lipoprotein (a), a lipoprotein of high atherogenicity, possesses proteolytic activity. In this report, we provide evidence that the lipoprotein (a)-specific antigen, apoprotein (a) is immunochemically related to plasminogen. This was demonstrated by polyclonal antisera from rabbit, sheep and horse, and with three monoclonal antibodies from mouse. Using immunospecific adsorbers against lipoprotein (a), all plasminogen could be adsorbed from lipoprotein (a)-positive and apparently lipoprotein (a)-negative plasma. As an additional similarity to plasminogen, lipoprotein (a) binds selectively to lysine-Sepharose, but with a somewhat lower affinity. In an assay system for measuring the fibrinolytic activity challenged with streptokinase, lipoprotein (a) prolonged strikingly the fibrinolysis time under certain experimental conditions.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume960
Issue number1
DOIs
Publication statusPublished - May 2 1988

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Lipoprotein(a)
Plasminogen
Apoprotein(a)
Streptokinase
Fibrinolysis
Lipoproteins
Horses
Immune Sera
Assays
Sheep
Monoclonal Antibodies
Rabbits
Plasmas
Antigens

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Endocrinology

Cite this

Lipoprotein (a) and plasminogen are immunochemically related. / Karádi, I.; Kostner, Gerhard M.; Gries, Anni; Nimpf, Johannes; Romics, Làszló; Malle, Ernst.

In: Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, Vol. 960, No. 1, 02.05.1988, p. 91-97.

Research output: Contribution to journalArticle

Karádi, I. ; Kostner, Gerhard M. ; Gries, Anni ; Nimpf, Johannes ; Romics, Làszló ; Malle, Ernst. / Lipoprotein (a) and plasminogen are immunochemically related. In: Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism. 1988 ; Vol. 960, No. 1. pp. 91-97.
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