Lipophilicity of substituted aurones and related compounds measured on immobilized artificial membrane (IAM) and conventional C8 (MOS) columns

Monika Huszár, Balázs Hallgas, M. Idei, Attila Kiss-Szikszai, Anikó Horváth, T. Patonay

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A high performance liquid chromatographic method utilizing an immobilized artificial membrane (IAM HPLC) column has been developed to separate the members of a library containing 38 aurone and thioaurone type structures and to characterise their lipophilicity. The experimental lipophilicity data (k′IAM) have been compared with the previously determined ones C8(MOS) column (k′MOS) and with their calculated lipophilicity parameters (CLOGP). In general, good correlations between the measured and calculated lipophilicities have been found both for the IAM and MOS column. The IAM column showed higher efficiency in separation of isomeric aurones or thioaurones than the MOS one and, consequently, it showed higher potential in differentiation of their lipophilicities. Our findings proved the usefulness of the HPLC method in fast characterisation of the lipophilicity of drug candidates closely related in structure.

Original languageEnglish
Pages (from-to)3143-3158
Number of pages16
JournalJournal of Liquid Chromatography and Related Technologies
Volume31
Issue number20
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Artificial Membranes
Membranes
High Pressure Liquid Chromatography
Libraries
aurone
Liquids
Pharmaceutical Preparations

Keywords

  • Aurone
  • Immobilized Artificial membrane (IAM) column
  • Lipophilicity
  • Molecular library
  • Retention factor
  • Thioaurones

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Biochemistry
  • Clinical Biochemistry

Cite this

Lipophilicity of substituted aurones and related compounds measured on immobilized artificial membrane (IAM) and conventional C8 (MOS) columns. / Huszár, Monika; Hallgas, Balázs; Idei, M.; Kiss-Szikszai, Attila; Horváth, Anikó; Patonay, T.

In: Journal of Liquid Chromatography and Related Technologies, Vol. 31, No. 20, 12.2008, p. 3143-3158.

Research output: Contribution to journalArticle

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