Lipophilicity determination of some nitrostyrene derivatives on RP-2, PR-8 and RP-18 layers

T. Cserhàti, A. Kiss-Tamàs, Gy Mikite

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Abstract

The lipophilicity of 33 nitrostyrene derivatives was determined by reversed-phase thin-layer chromatography on RP-2, RP-8 and RP-18 layers using methanol as the organic phase. The RM value of each compound linearly decreased with increasing concentration of the organic solvent. The retention strength of RP-2 layer was lower than that of RP-8 and RP-18 layers. Between the retention strength of RP-8 and RP-18 layers no significant difference was detected. Minor differences among the selectivities of the layers were also observed. The impact of the change of methanol concentration on the retention was higher on RP-2 than on RP-18 layers probably due to the sterically favourable interaction of methanol with the shorter alkyl groups on the silica surface.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalChromatographia
Volume25
Issue number2
DOIs
Publication statusPublished - Feb 1 1988

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Keywords

  • Lipophilic character
  • Nitrostyrene derivatives
  • RP-2, RP-8 and RP-18 layers
  • Thin-layer chromatography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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