Lipophilicity determination of some monoamine oxidase inhibitors by reversed-phase thin-layer chromatography. The effect of pH

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Abstract

The lipophilicity (R(M) value) of 17 monoamine oxidase inhibitory drugs was determined by reversed-phase thin-layer chromatography and the effect of various eluent additives such as acetic acid, sodium acetate and sodium chloride on the retention was studied. Each drug exhibited regular retention behavior, their R(M) value linearly decreased with the increasing concentration of methanol in the eluent. Acetic acid decreased the retention, the effect was higher at lower acid concentrations which indicates that the phenomena is of saturation character. The effect of sodiumchloride and sodiumacetate was negligible. The lipophilicity and specific hydrophobic surface area values of the drugs were intercorrelated, however, their information content is different, therefore their simultaneous application in quantitative structure-activity relationship studies is recommended.

Original languageEnglish
Pages (from-to)1805-1817
Number of pages13
JournalJournal of Liquid Chromatography
Volume16
Issue number8
Publication statusPublished - 1993

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Thin layer chromatography
Monoamine Oxidase Inhibitors
Reverse-Phase Chromatography
Thin Layer Chromatography
Acetic Acid
Pharmaceutical Preparations
Sodium Acetate
Quantitative Structure-Activity Relationship
Monoamine Oxidase
Sodium Chloride
Methanol
Acids

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

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AB - The lipophilicity (R(M) value) of 17 monoamine oxidase inhibitory drugs was determined by reversed-phase thin-layer chromatography and the effect of various eluent additives such as acetic acid, sodium acetate and sodium chloride on the retention was studied. Each drug exhibited regular retention behavior, their R(M) value linearly decreased with the increasing concentration of methanol in the eluent. Acetic acid decreased the retention, the effect was higher at lower acid concentrations which indicates that the phenomena is of saturation character. The effect of sodiumchloride and sodiumacetate was negligible. The lipophilicity and specific hydrophobic surface area values of the drugs were intercorrelated, however, their information content is different, therefore their simultaneous application in quantitative structure-activity relationship studies is recommended.

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