Lipophilicity determination of some fully protected peptides and amino acids

T. Cserháti, B. Bordás, G. Ösapay

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22 Citations (Scopus)


The lipophilicity of 21 fully protected peptides and amino acids was determined by reversed-phase thin-layer chromatography. The RM values decreased linearly with growing methanol concentration of the eluent. The sequence and conformation of molecular substructures did not significantly influence the lipophilicity. The presence of salt and ammonia in the eluent had a negligible impact on retention; the effect of the pH value was also low. In the presence of 1M and 2M acetic acid the retention of each compound considerably decreased. Acetic acid also changed markedly the selectivity. Our data suggest that the acetic acid has a preponderant role in changing the retention and selectivity of fully protected peptides and amino acids in reversedphase thin-layer chromatography.

Original languageEnglish
Pages (from-to)184-188
Number of pages5
Issue number3
Publication statusPublished - Mar 1 1987


  • Amino acid analysis
  • Peptide analysis
  • Reversed-phase chromatography
  • Thin-layer chromatography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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