Lipids associated with tissue transglutaminase

J. Hársfalvi, Gabriella Arato, L. Fésüs

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A substantial amount of lipids (cholesterol and its esters, mono, di- and triacylgylcerols, free fatty acids and the phospholipids phosphatidylethanolamine and phosphatidylinositol) was found associated with tissue transglutaminase purified to apparent homogeneity from guinea pig liver. Removal of lipids results in an increased tendendy of the enzyme for self-association and a decreased stability. Lauric acid was detected following hydroxylamine treatment of the enzyme, suggesting the occurrence of a fatty acid-type, covalent, posttranslational modification of transglutaminase. The results provide support for the idea that part of tissue transglutaminase may be localized in the cell membrane.

Original languageEnglish
Pages (from-to)42-45
Number of pages4
JournalBBA - General Subjects
Volume923
Issue number1
DOIs
Publication statusPublished - Jan 20 1987

Fingerprint

lauric acid
Lipids
Hydroxylamine
Transglutaminases
Cholesterol Esters
Enzymes
Cell membranes
Post Translational Protein Processing
Phosphatidylinositols
Nonesterified Fatty Acids
Liver
Phospholipids
Guinea Pigs
Fatty Acids
Cell Membrane
transglutaminase 2
phosphatidylethanolamine

Keywords

  • Covalent modification
  • Lauric acid
  • Membrane association
  • Neutral lipid
  • Phospholipid
  • Transglutaminase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Lipids associated with tissue transglutaminase. / Hársfalvi, J.; Arato, Gabriella; Fésüs, L.

In: BBA - General Subjects, Vol. 923, No. 1, 20.01.1987, p. 42-45.

Research output: Contribution to journalArticle

Hársfalvi, J. ; Arato, Gabriella ; Fésüs, L. / Lipids associated with tissue transglutaminase. In: BBA - General Subjects. 1987 ; Vol. 923, No. 1. pp. 42-45.
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