Lipid-rich cell thyroid adenoma

histopathology with comparative lipid analysis

K. Tóth, I. Péter, T. Kremmer, J. Sugár

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A second case of the unique lipid-rich cell thyroid adenoma is described complemented by detailed lipid analysis. New observations were made. The cytoplasm of the tumour cells contained scattered, aggregated sudanophil crystals; under polarized light the frozen, unstained sections exhibited numerous birefringent lipid crystals; electron microscopy provided further evidence that the clear cell appearance was due to intracellular lipid droplets with scanty glycogen particles. Comparative lipid analysis by thin layer chromatography and high-pressure liquid chromatography (HPLC) revealed quantitative and qualitative differences in lipid composition of tumour cells when compared with goitre cells from normal thyroid gland and subcutane fat. Qualitative differences in triglyceride composition (by HPLC) between tumour cells and subcutaneous fat indicated that the fat accumulation in the follicle cells was not a result of simple storage, but an expression of altered intracellular lipid metabolism.

Original languageEnglish
Pages (from-to)273-276
Number of pages4
JournalVirchows Archiv A Pathological Anatomy and Histopathology
Volume417
Issue number3
DOIs
Publication statusPublished - May 1990

Fingerprint

Thyroid Neoplasms
Lipids
Fats
High Pressure Liquid Chromatography
Neoplasms
Subcutaneous Fat
Goiter
Frozen Sections
Thin Layer Chromatography
Glycogen
Lipid Metabolism
Electron Microscopy
Thyroid Gland
Cytoplasm
Triglycerides
Light

Keywords

  • Crystals
  • Lipid analysis
  • Lipid-rich cell adenoma
  • Subcutaneous fat
  • Thyroid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Anatomy

Cite this

Lipid-rich cell thyroid adenoma : histopathology with comparative lipid analysis. / Tóth, K.; Péter, I.; Kremmer, T.; Sugár, J.

In: Virchows Archiv A Pathological Anatomy and Histopathology, Vol. 417, No. 3, 05.1990, p. 273-276.

Research output: Contribution to journalArticle

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