Lipid rafts, cholesterol, and the brain

Z. Korade, Anne K. Kenworthy

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

Lipid rafts are specialized membrane microdomains that serve as organizing centers for assembly of signaling molecules, influence membrane fluidity and trafficking of membrane proteins, and regulate different cellular processes such as neurotransmission and receptor trafficking. In this article, we provide an overview of current methods for studying lipid rafts and models for how lipid rafts might form and function. Next, we propose a potential mechanism for regulating lipid rafts in the brain via local control of cholesterol biosynthesis by neurotrophins and their receptors. Finally, we discuss evidence that altered cholesterol metabolism and/or lipid rafts play a critical role in the pathophysiology of multiple CNS disorders, including Smith-Lemli-Opitz syndrome, Huntington's, Alzheimer's, and Niemann-Pick Type C diseases.

Original languageEnglish
Pages (from-to)1265-1273
Number of pages9
JournalNeuropharmacology
Volume55
Issue number8
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Cholesterol
Lipids
Brain
Smith-Lemli-Opitz Syndrome
Type C Niemann-Pick Disease
Membrane Microdomains
Nerve Growth Factor Receptors
Membrane Fluidity
Lipid Metabolism
Synaptic Transmission
Membrane Proteins

Keywords

  • Brain
  • Cholesterol
  • Growth factors (neurotrophins)
  • Lipid rafts
  • Myelin
  • Neurodegenerative disorders

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Lipid rafts, cholesterol, and the brain. / Korade, Z.; Kenworthy, Anne K.

In: Neuropharmacology, Vol. 55, No. 8, 12.2008, p. 1265-1273.

Research output: Contribution to journalArticle

Korade, Z. ; Kenworthy, Anne K. / Lipid rafts, cholesterol, and the brain. In: Neuropharmacology. 2008 ; Vol. 55, No. 8. pp. 1265-1273.
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