Lipid peroxidation in lung of rats exposed to hyperoxic, hypoxic and ischemic effects.

B. Török, E. Rőth, T. Zsoldos, A. Tigyi, B. Matkovics, L. Szabó

Research output: Contribution to journalArticle

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Abstract

Rat experiments were undertaken to describe the range of the endogenous lipid peroxidation (measured by formation of malondialdehyde [MDA] in lung tissue) and to analyze the effects of hyperoxic, hypoxic and ischemic influences. The acute hyperoxia caused a moderate increase in lipid peroxidation. The MDA formation in lungs of rats was perceptibly higher in low oxygen environment, while the highest values were found in ischemic lungs. The cytotoxic metabolites cause unfavourable influences on the lung structure (perivascular, interstitial and alveolar edema, destroyed epithelial lining with disintegration of lamellar membranes of the type II-pneumocytes). The findings suggest that potential danger of the oxygen free radicals is an increased lipid peroxidation of lung tissue causing alveolocapillary destruction and extensive exudation with pathologic dwindling of lung function.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalExperimental Pathology
Volume29
Issue number4
Publication statusPublished - 1986

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Lipid Peroxidation
Rats
Malondialdehyde
Lipids
Lung
Tissue
Oxygen
Disintegration
Metabolites
Linings
Free Radicals
Membranes
Alveolar Epithelial Cells
Hyperoxia
Reactive Oxygen Species
Edema
Experiments

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Lipid peroxidation in lung of rats exposed to hyperoxic, hypoxic and ischemic effects. / Török, B.; Rőth, E.; Zsoldos, T.; Tigyi, A.; Matkovics, B.; Szabó, L.

In: Experimental Pathology, Vol. 29, No. 4, 1986, p. 221-226.

Research output: Contribution to journalArticle

Török, B. ; Rőth, E. ; Zsoldos, T. ; Tigyi, A. ; Matkovics, B. ; Szabó, L. / Lipid peroxidation in lung of rats exposed to hyperoxic, hypoxic and ischemic effects. In: Experimental Pathology. 1986 ; Vol. 29, No. 4. pp. 221-226.
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