Lipid peroxidation and antioxidant system changes in acute L-arginine pancreatitis in rats

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7 Citations (Scopus)

Abstract

The important role of oxygen radicals in acute experimental pancreatitis was demonstrated by study of the changes in the antioxidant system in the blood, liver, kidney and pancreas of rats after the administration of a large quantity of L-arginine (L-Arg). The changes in lipid peroxidation and in reduced and oxidized glutathione were followed as well as the activities of peroxide-decomposing enzymes (glutathione peroxidase and catalase) and H2O2-producing superoxide dismutases. The results demonstrated that acute pancreatitis and 'oxidative stress' develop rapidly after L-Arg treatment. 'Oxidative stress' symptoms are expressed 24 hours after the final treatment. Slow restitution of the studied antioxidant system can be demonstrated as early as after 48 hours.

Original languageEnglish
Pages (from-to)129-138
Number of pages10
JournalActa Physiologica Hungarica
Volume85
Issue number2
Publication statusPublished - 1997

Fingerprint

Pancreatitis
Lipid Peroxidation
Arginine
Oxidative Stress
Antioxidants
Glutathione Disulfide
Peroxides
Glutathione Peroxidase
Catalase
Superoxide Dismutase
Glutathione
Pancreas
Reactive Oxygen Species
Kidney
Liver
Enzymes

Keywords

  • Acute pancreatitis
  • Antioxidant enzymes
  • L-Arg
  • LP

ASJC Scopus subject areas

  • Physiology

Cite this

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abstract = "The important role of oxygen radicals in acute experimental pancreatitis was demonstrated by study of the changes in the antioxidant system in the blood, liver, kidney and pancreas of rats after the administration of a large quantity of L-arginine (L-Arg). The changes in lipid peroxidation and in reduced and oxidized glutathione were followed as well as the activities of peroxide-decomposing enzymes (glutathione peroxidase and catalase) and H2O2-producing superoxide dismutases. The results demonstrated that acute pancreatitis and 'oxidative stress' develop rapidly after L-Arg treatment. 'Oxidative stress' symptoms are expressed 24 hours after the final treatment. Slow restitution of the studied antioxidant system can be demonstrated as early as after 48 hours.",
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T1 - Lipid peroxidation and antioxidant system changes in acute L-arginine pancreatitis in rats

AU - Varga, I.

AU - Matkovics, B.

AU - Hai, Do Quy

AU - Kotormán, M.

AU - Takács, T.

AU - Sasvári, M.

PY - 1997

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N2 - The important role of oxygen radicals in acute experimental pancreatitis was demonstrated by study of the changes in the antioxidant system in the blood, liver, kidney and pancreas of rats after the administration of a large quantity of L-arginine (L-Arg). The changes in lipid peroxidation and in reduced and oxidized glutathione were followed as well as the activities of peroxide-decomposing enzymes (glutathione peroxidase and catalase) and H2O2-producing superoxide dismutases. The results demonstrated that acute pancreatitis and 'oxidative stress' develop rapidly after L-Arg treatment. 'Oxidative stress' symptoms are expressed 24 hours after the final treatment. Slow restitution of the studied antioxidant system can be demonstrated as early as after 48 hours.

AB - The important role of oxygen radicals in acute experimental pancreatitis was demonstrated by study of the changes in the antioxidant system in the blood, liver, kidney and pancreas of rats after the administration of a large quantity of L-arginine (L-Arg). The changes in lipid peroxidation and in reduced and oxidized glutathione were followed as well as the activities of peroxide-decomposing enzymes (glutathione peroxidase and catalase) and H2O2-producing superoxide dismutases. The results demonstrated that acute pancreatitis and 'oxidative stress' develop rapidly after L-Arg treatment. 'Oxidative stress' symptoms are expressed 24 hours after the final treatment. Slow restitution of the studied antioxidant system can be demonstrated as early as after 48 hours.

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