Lipase-catalyzed enantiomer selective hydrolysis of 1,2-diol diacetates

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Enantiomer selective hydrolysis of racemic 1,2-diol diacetates (rac-2a-h) was investigated by using the inexpensive commercial porcine pancreatic lipase. The hydrolysis proceeds with variable regioselectivity but with moderate to good enantioselectivity yielding a mixture of isomeric monoacetates (3a-h and 4a-h) and unchanged diacetate enantiomers (2a-h). Evidence was found that both monoacetates (3a-h and 4a-h) are formed with the same sense of enantiomer selectivity.

Original languageEnglish
Pages (from-to)2211-2217
Number of pages7
JournalTetrahedron Asymmetry
Volume4
Issue number10
DOIs
Publication statusPublished - 1993

Fingerprint

Enantiomers
enantiomers
Lipases
Lipase
hydrolysis
Hydrolysis
Regioselectivity
Swine
Enantioselectivity
selectivity

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

Lipase-catalyzed enantiomer selective hydrolysis of 1,2-diol diacetates. / Poppe, L.; Novák, L.; Kajtár-Peredy, M.; Szántay, Csaba.

In: Tetrahedron Asymmetry, Vol. 4, No. 10, 1993, p. 2211-2217.

Research output: Contribution to journalArticle

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