2-[(dialkil-amino)-metil]-ciklanolok enzimes rezolvalasa. Osszehasonlito vizsgalatok

Translated title of the contribution: Lipase-catalysed resolution of 2-dialkylaminomethylcyclanols. Comparative studies

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Extensive lipase screening was performed in relation to the asymmetric acetylation of rac-2-dialkylaminomethylcyclanols (1-6). The lipase PS- and Novozym 435-catalysed resolutions of 1-6 with various vinyl esters were studied in different organic media. High enantioselectivity (E > 200) was observed when vinyl acetate was used as acylating agent and diethyl ether as solvent. The (1R,2R) enantiomers react preferentially in the case of the cis isomers, whereas the (1R,2S) enantiomers do so in the case of the trans counterparts. The enantioselective acetylation of the five-membered amino alcohols (1, 3 and 5) proceeded much more rapidly than that of the six- membered amino alcohols (2, 4 and 6). The reaction rates were also affected by the solvent and by the quantity of the enzyme.

Original languageHungarian
Pages (from-to)155-158
Number of pages4
JournalActa Pharmaceutica Hungarica
Volume69
Issue number3
Publication statusPublished - Jun 1999

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Amino Alcohols
Acetylation
Lipase
Ether
Esters
Enzymes
vinyl acetate
Novozyme 435

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

2-[(dialkil-amino)-metil]-ciklanolok enzimes rezolvalasa. Osszehasonlito vizsgalatok. / Forró, E.; Fülöp, F.

In: Acta Pharmaceutica Hungarica, Vol. 69, No. 3, 06.1999, p. 155-158.

Research output: Contribution to journalArticle

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