Lipase-catalysed resolution of 2-dialkylaminomethyicyclohexanols

Enikõ Forró, Liisa T. Kanerva, Ferenc Fülöp

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The lipase PS- and Novozym 435-catalysed resolutions of 2- dialkylaminomethylcyclohexanols (A-F) with various vinyl esters were studied in different organic media. High enantioselectivity (E>200) was observed when vinyl acetate was used as an acylating agent and diethyl ether as a solvent. The (1R,2R) enantiomers react preferentially in the case of the cis isomers, whereas the (1R,2S) enantiomers do so in the case of the trans counterparts. Reaction rates were markedly affected by the solvent and by the quantity of the enzyme.

Original languageEnglish
Pages (from-to)513-520
Number of pages8
JournalTetrahedron Asymmetry
Volume9
Issue number3
DOIs
Publication statusPublished - Feb 13 1998

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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