Lipase-catalysed N-acylation of β2-amino esters

Mónika Fitz, Eniko Forró, Edina Vigóczki, László Lázár, Ferenc Fülöp

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The Candida antarctica lipase A-catalysed N-acylation of ethyl 3-amino-2-ethylpropanoate rac-3 and methyl 3-amino-2-isopropylpropanoate rac-6 was performed with ethyl butanoate in tert-amyl alcohol at 4 °C. The resulting enantiomerically enriched derivatives were isolated as N-Boc-protected amino esters (R)-9 and (R)-10 and butyramides (S)-7 and (S)-8 (ee: 76-95%).

Original languageEnglish
Pages (from-to)1114-1119
Number of pages6
JournalTetrahedron Asymmetry
Volume19
Issue number9
DOIs
Publication statusPublished - May 16 2008

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ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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