Lipase-catalysed kinetic resolution of hydroxymethylchromanes

A. Czompa, T. Kovacs, S. Antus

Research output: Contribution to journalArticle

6 Citations (Scopus)


An effective kinetic resolution of hydroxymethylchromanes racemic 2a and 3a has been achieved by means of enantioselective transesterification with vinyl acetate in organic solvents. The alcohols (-)-R-2a and (-)-S-3a were obtained with high optical purities (94 and 98% ee) in 70% and 38% yields, respectively. The influence of the enzyme source and the character of the solvent on the enantioselectivity were studied.

Original languageEnglish
Pages (from-to)991-995
Number of pages5
JournalJournal of Heterocyclic Chemistry
Issue number4
Publication statusPublished - Jan 1 2000

ASJC Scopus subject areas

  • Organic Chemistry

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