linc00673 (ERRLR01) is a prognostic indicator of overall survival in breast cancer

Ubaidat Abdul-Rahman, B. Györffy, Brian D. Adams

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

LncRNAs are novel noncoding RNAs involved in the epigenetic regulation of gene expression by recruiting ribonucleoprotein complexes to specific genomic loci to initiate histone methylation and/or other chromatin modifications. LncRNAs themselves function as tumor suppressors or oncogenes, depending on the gene regulatory networks they govern. We identified lnc00673 (ERRLR01) as a marker of overall survival (OS) in breast cancer patients. Specifically, ERRLR01 levels were elevated in triple-negative breast cancer (TNBC) as compared with Luminal-A, Luminal-B, and HER2 breast cancer subtypes. ERRLR01 levels were also inversely correlated with breast cancer survival across all breast cancer patients. Upon stratification, OS in ERα tumors correlated with negative overall survival, while in ERα+ tumors, ERRLR01 correlated with positive outcomes. This suggests ERRLR01 is modulated by hormone signaling in breast cancer. Gene-network analysis revealed ERRLR01 correlated with distinct pathways including “epithelial development” and “cellular differentiation.” These data suggest ERRLR01 operates as an oncogene in TNBC, as well as a biomarker in breast cancer patients.

Original languageEnglish
Pages (from-to)17-29
Number of pages13
JournalTranscription
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Tumors
Phenobarbital
Breast Neoplasms
Survival
Genes
Triple Negative Breast Neoplasms
Untranslated RNA
Methylation
Ribonucleoproteins
Gene Regulatory Networks
Biomarkers
Electric network analysis
Oncogenes
Gene expression
Histones
Chromatin
Hormones
Neoplasms
Gene Expression Regulation
Epigenomics

Keywords

  • breast cancer
  • ERRLR01
  • estrogen signaling
  • hormone-regulation
  • lncRNA
  • survival outcomes

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Genetics

Cite this

linc00673 (ERRLR01) is a prognostic indicator of overall survival in breast cancer. / Abdul-Rahman, Ubaidat; Györffy, B.; Adams, Brian D.

In: Transcription, Vol. 9, No. 1, 01.01.2018, p. 17-29.

Research output: Contribution to journalArticle

Abdul-Rahman, Ubaidat ; Györffy, B. ; Adams, Brian D. / linc00673 (ERRLR01) is a prognostic indicator of overall survival in breast cancer. In: Transcription. 2018 ; Vol. 9, No. 1. pp. 17-29.
@article{5dfd2706222a4b22a28c8988c2392fe7,
title = "linc00673 (ERRLR01) is a prognostic indicator of overall survival in breast cancer",
abstract = "LncRNAs are novel noncoding RNAs involved in the epigenetic regulation of gene expression by recruiting ribonucleoprotein complexes to specific genomic loci to initiate histone methylation and/or other chromatin modifications. LncRNAs themselves function as tumor suppressors or oncogenes, depending on the gene regulatory networks they govern. We identified lnc00673 (ERRLR01) as a marker of overall survival (OS) in breast cancer patients. Specifically, ERRLR01 levels were elevated in triple-negative breast cancer (TNBC) as compared with Luminal-A, Luminal-B, and HER2 breast cancer subtypes. ERRLR01 levels were also inversely correlated with breast cancer survival across all breast cancer patients. Upon stratification, OS in ERα− tumors correlated with negative overall survival, while in ERα+ tumors, ERRLR01 correlated with positive outcomes. This suggests ERRLR01 is modulated by hormone signaling in breast cancer. Gene-network analysis revealed ERRLR01 correlated with distinct pathways including “epithelial development” and “cellular differentiation.” These data suggest ERRLR01 operates as an oncogene in TNBC, as well as a biomarker in breast cancer patients.",
keywords = "breast cancer, ERRLR01, estrogen signaling, hormone-regulation, lncRNA, survival outcomes",
author = "Ubaidat Abdul-Rahman and B. Gy{\"o}rffy and Adams, {Brian D.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1080/21541264.2017.1329684",
language = "English",
volume = "9",
pages = "17--29",
journal = "Transcription",
issn = "2154-1264",
publisher = "Friedrich-Berlin-Verlag",
number = "1",

}

TY - JOUR

T1 - linc00673 (ERRLR01) is a prognostic indicator of overall survival in breast cancer

AU - Abdul-Rahman, Ubaidat

AU - Györffy, B.

AU - Adams, Brian D.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - LncRNAs are novel noncoding RNAs involved in the epigenetic regulation of gene expression by recruiting ribonucleoprotein complexes to specific genomic loci to initiate histone methylation and/or other chromatin modifications. LncRNAs themselves function as tumor suppressors or oncogenes, depending on the gene regulatory networks they govern. We identified lnc00673 (ERRLR01) as a marker of overall survival (OS) in breast cancer patients. Specifically, ERRLR01 levels were elevated in triple-negative breast cancer (TNBC) as compared with Luminal-A, Luminal-B, and HER2 breast cancer subtypes. ERRLR01 levels were also inversely correlated with breast cancer survival across all breast cancer patients. Upon stratification, OS in ERα− tumors correlated with negative overall survival, while in ERα+ tumors, ERRLR01 correlated with positive outcomes. This suggests ERRLR01 is modulated by hormone signaling in breast cancer. Gene-network analysis revealed ERRLR01 correlated with distinct pathways including “epithelial development” and “cellular differentiation.” These data suggest ERRLR01 operates as an oncogene in TNBC, as well as a biomarker in breast cancer patients.

AB - LncRNAs are novel noncoding RNAs involved in the epigenetic regulation of gene expression by recruiting ribonucleoprotein complexes to specific genomic loci to initiate histone methylation and/or other chromatin modifications. LncRNAs themselves function as tumor suppressors or oncogenes, depending on the gene regulatory networks they govern. We identified lnc00673 (ERRLR01) as a marker of overall survival (OS) in breast cancer patients. Specifically, ERRLR01 levels were elevated in triple-negative breast cancer (TNBC) as compared with Luminal-A, Luminal-B, and HER2 breast cancer subtypes. ERRLR01 levels were also inversely correlated with breast cancer survival across all breast cancer patients. Upon stratification, OS in ERα− tumors correlated with negative overall survival, while in ERα+ tumors, ERRLR01 correlated with positive outcomes. This suggests ERRLR01 is modulated by hormone signaling in breast cancer. Gene-network analysis revealed ERRLR01 correlated with distinct pathways including “epithelial development” and “cellular differentiation.” These data suggest ERRLR01 operates as an oncogene in TNBC, as well as a biomarker in breast cancer patients.

KW - breast cancer

KW - ERRLR01

KW - estrogen signaling

KW - hormone-regulation

KW - lncRNA

KW - survival outcomes

UR - http://www.scopus.com/inward/record.url?scp=85030553798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030553798&partnerID=8YFLogxK

U2 - 10.1080/21541264.2017.1329684

DO - 10.1080/21541264.2017.1329684

M3 - Article

C2 - 28795861

AN - SCOPUS:85030553798

VL - 9

SP - 17

EP - 29

JO - Transcription

JF - Transcription

SN - 2154-1264

IS - 1

ER -