linc00673 (ERRLR01) is a prognostic indicator of overall survival in breast cancer

Ubaidat Abdul-Rahman, Balázs Győrffy, Brian D. Adams

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

LncRNAs are novel noncoding RNAs involved in the epigenetic regulation of gene expression by recruiting ribonucleoprotein complexes to specific genomic loci to initiate histone methylation and/or other chromatin modifications. LncRNAs themselves function as tumor suppressors or oncogenes, depending on the gene regulatory networks they govern. We identified lnc00673 (ERRLR01) as a marker of overall survival (OS) in breast cancer patients. Specifically, ERRLR01 levels were elevated in triple-negative breast cancer (TNBC) as compared with Luminal-A, Luminal-B, and HER2 breast cancer subtypes. ERRLR01 levels were also inversely correlated with breast cancer survival across all breast cancer patients. Upon stratification, OS in ERα tumors correlated with negative overall survival, while in ERα+ tumors, ERRLR01 correlated with positive outcomes. This suggests ERRLR01 is modulated by hormone signaling in breast cancer. Gene-network analysis revealed ERRLR01 correlated with distinct pathways including “epithelial development” and “cellular differentiation.” These data suggest ERRLR01 operates as an oncogene in TNBC, as well as a biomarker in breast cancer patients.

Original languageEnglish
Pages (from-to)17-29
Number of pages13
JournalTranscription
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • ERRLR01
  • breast cancer
  • estrogen signaling
  • hormone-regulation
  • lncRNA
  • survival outcomes

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Genetics

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