Linalool-induced oxidative stress processes in the human pathogen Candida albicans

Gábor Máté, Dominika Kovács, Zoltán Gazdag, Miklós Pesti, Árpád Szántó

Research output: Contribution to journalArticle

2 Citations (Scopus)


The present study investigated the linalool (Lol)-induced effects in acute toxicity tests in the human pathogen Candida albicans (C. albicans). Lol treatments induced reduced germ tube formation of the pathogen, which plays a crucial role in the virulence. In comparison with the untreated control, the exposure of 107 cells ml-1 to 0.7 mM or 1.4 mM Lol for one hour induced 20% and 30% decrements, respectively, in the colony-forming ability. At the same time, these treatments caused dose-dependent decrease in the levels of superoxide anion radical and total reactive oxygen species, while there was 1.5 and 1.8-fold increases in the concentrations of peroxides and lipid peroxides, respectively, indicating oxidative stress induction in the presence of Lol. Lol treatments resulted in different adaptive modifications of the antioxidant system. In 0.7 mM-treated cells, decreased specific activities of superoxide dismutase and catalase were detected, while exposure to 1.4 mM Lol resulted in the up-regulation of catalase, glutathione reductase and glutathione peroxidases.

Original languageEnglish
Pages (from-to)220-231
Number of pages12
JournalActa biologica Hungarica
Issue number2
Publication statusPublished - Jun 2017


  • Antioxidant enzyme
  • Candida albicans
  • Linalool
  • Oxidative stress
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

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