Linalool-induced oxidative stress processes in the human pathogen Candida albicans

Gábor Máté, Dominika Kovács, Zoltán Gazdag, M. Pesti, Árpád Szántó

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The present study investigated the linalool (Lol)-induced effects in acute toxicity tests in the human pathogen Candida albicans (C. albicans). Lol treatments induced reduced germ tube formation of the pathogen, which plays a crucial role in the virulence. In comparison with the untreated control, the exposure of 107 cells ml-1 to 0.7 mM or 1.4 mM Lol for one hour induced 20% and 30% decrements, respectively, in the colony-forming ability. At the same time, these treatments caused dose-dependent decrease in the levels of superoxide anion radical and total reactive oxygen species, while there was 1.5 and 1.8-fold increases in the concentrations of peroxides and lipid peroxides, respectively, indicating oxidative stress induction in the presence of Lol. Lol treatments resulted in different adaptive modifications of the antioxidant system. In 0.7 mM-treated cells, decreased specific activities of superoxide dismutase and catalase were detected, while exposure to 1.4 mM Lol resulted in the up-regulation of catalase, glutathione reductase and glutathione peroxidases.

Original languageEnglish
Pages (from-to)220-231
Number of pages12
JournalActa Biologica Hungarica
Volume68
Issue number2
DOIs
Publication statusPublished - Jun 1 2017

Fingerprint

Oxidative stress
Candida
Pathogens
Candida albicans
Oxidative Stress
pathogen
virulence
toxicity test
antioxidant
anion
lipid
toxicity
fold
Superoxides
Catalase
Acute Toxicity Tests
Glutathione Reductase
Lipid Peroxides
Peroxides
Glutathione Peroxidase

Keywords

  • Antioxidant enzyme
  • Candida albicans
  • Linalool
  • Oxidative stress
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

Cite this

Linalool-induced oxidative stress processes in the human pathogen Candida albicans. / Máté, Gábor; Kovács, Dominika; Gazdag, Zoltán; Pesti, M.; Szántó, Árpád.

In: Acta Biologica Hungarica, Vol. 68, No. 2, 01.06.2017, p. 220-231.

Research output: Contribution to journalArticle

Máté, Gábor ; Kovács, Dominika ; Gazdag, Zoltán ; Pesti, M. ; Szántó, Árpád. / Linalool-induced oxidative stress processes in the human pathogen Candida albicans. In: Acta Biologica Hungarica. 2017 ; Vol. 68, No. 2. pp. 220-231.
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