Light microscopic localization of acid phosphatase in different tissue cells of the albino rat

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Abstract

The enzyme acid phosphatase (orthophosphoric monoester phosphohydrolase, EC 3.1. 3.2), often referred to as 'non-specific acid phosphomonoesterase' because of histochemical and biochemical polymorphisms and ubiquity, is one of the most thoroughly studied enzymes in mammalian tissue. The aim of the present work was to outline the functional characteristics of this enzyme by extrapolating the results of light microscopic investigations. A diffuse intracytoplasmic acid phosphatase activity was detected in the epinephrine-producing cells of the adrenal medulla. Various forms of lysosomes were observed to exert acid phosphatase activity in bronchial and bronchiolar epithelia, hepatocytes, Kupffer cells and in the walls of brain vessels. Pseudounipolar ganglion cells and certain neurons of the medulla oblongata were found to contain acid phosphatase in intracellular membrane systems. Biochemically, acid phosphatase consists of more than four isozymes, each of them possessing antigenically diverse molecular forms suggesting molecular polymorphism. Histochemical and biochemical polymorphisms of acid phosphatase are considered to be due to the accommodation to the pleomorphic appearance of a sole chemical bond.

Original languageEnglish
Pages (from-to)771-784
Number of pages14
JournalZeitschrift fur Mikroskopisch-Anatomische Forschung - Abteilung 2
Volume94
Issue number5
Publication statusPublished - 1980

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Acid Phosphatase
Light
Phosphoric Monoester Hydrolases
Enzymes
Medulla Oblongata
Intracellular Membranes
Adrenal Medulla
Kupffer Cells
Lysosomes
Ganglia
Cell Wall
Epinephrine
Isoenzymes
Hepatocytes
Epithelium
Neurons
Acids
Brain

ASJC Scopus subject areas

  • Anatomy

Cite this

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abstract = "The enzyme acid phosphatase (orthophosphoric monoester phosphohydrolase, EC 3.1. 3.2), often referred to as 'non-specific acid phosphomonoesterase' because of histochemical and biochemical polymorphisms and ubiquity, is one of the most thoroughly studied enzymes in mammalian tissue. The aim of the present work was to outline the functional characteristics of this enzyme by extrapolating the results of light microscopic investigations. A diffuse intracytoplasmic acid phosphatase activity was detected in the epinephrine-producing cells of the adrenal medulla. Various forms of lysosomes were observed to exert acid phosphatase activity in bronchial and bronchiolar epithelia, hepatocytes, Kupffer cells and in the walls of brain vessels. Pseudounipolar ganglion cells and certain neurons of the medulla oblongata were found to contain acid phosphatase in intracellular membrane systems. Biochemically, acid phosphatase consists of more than four isozymes, each of them possessing antigenically diverse molecular forms suggesting molecular polymorphism. Histochemical and biochemical polymorphisms of acid phosphatase are considered to be due to the accommodation to the pleomorphic appearance of a sole chemical bond.",
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