Light microscopic histochemistry of the postnatal development and localization of carbonic anhydrase activity in glial and neuronal cell types of the rat central nervous system

A. Nógrádi, A. Mihály

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The postnatal expression of carbonic anhydrase (CA) activity in glia and neurons was investigated by a modified light microscopical method of Hansson. Strong CA activity was observed during the first postnatal week in ameboid microglia, clustering in the cingulum, the periaqueductal region, the roof of the lateral ventricles and the white matter of the cerebellum. The intensity of staining gradually decreased during the second week and finally disappeared. From the 9th postnatal day on, cerebellar Purkinje cells expressed strong CA activity, which completely disappeared by the end of the investigation period. CA staining of the oligodendrocytes and pericytes could be observed from the first postnatal day on. The present results raised the possibility that carbonic anhydrase activity may play a role in the regulation of the development and proliferation of some cell types, perhaps via intracellular pH changes.

Original languageEnglish
Pages (from-to)441-447
Number of pages7
JournalHistochemistry
Volume94
Issue number4
DOIs
Publication statusPublished - Aug 1990

Fingerprint

Carbonic Anhydrases
Neuroglia
Central Nervous System
Light
Staining and Labeling
Pericytes
Lateral Ventricles
Purkinje Cells
Oligodendroglia
Microglia
Cerebellum
Cluster Analysis
Cell Proliferation
Neurons

ASJC Scopus subject areas

  • Anatomy

Cite this

@article{9e8803e3368646ce8d534d0b9136c65c,
title = "Light microscopic histochemistry of the postnatal development and localization of carbonic anhydrase activity in glial and neuronal cell types of the rat central nervous system",
abstract = "The postnatal expression of carbonic anhydrase (CA) activity in glia and neurons was investigated by a modified light microscopical method of Hansson. Strong CA activity was observed during the first postnatal week in ameboid microglia, clustering in the cingulum, the periaqueductal region, the roof of the lateral ventricles and the white matter of the cerebellum. The intensity of staining gradually decreased during the second week and finally disappeared. From the 9th postnatal day on, cerebellar Purkinje cells expressed strong CA activity, which completely disappeared by the end of the investigation period. CA staining of the oligodendrocytes and pericytes could be observed from the first postnatal day on. The present results raised the possibility that carbonic anhydrase activity may play a role in the regulation of the development and proliferation of some cell types, perhaps via intracellular pH changes.",
author = "A. N{\'o}gr{\'a}di and A. Mih{\'a}ly",
year = "1990",
month = "8",
doi = "10.1007/BF00266453",
language = "English",
volume = "94",
pages = "441--447",
journal = "Histochemie. Histochemistry. Histochimie",
issn = "0948-6143",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Light microscopic histochemistry of the postnatal development and localization of carbonic anhydrase activity in glial and neuronal cell types of the rat central nervous system

AU - Nógrádi, A.

AU - Mihály, A.

PY - 1990/8

Y1 - 1990/8

N2 - The postnatal expression of carbonic anhydrase (CA) activity in glia and neurons was investigated by a modified light microscopical method of Hansson. Strong CA activity was observed during the first postnatal week in ameboid microglia, clustering in the cingulum, the periaqueductal region, the roof of the lateral ventricles and the white matter of the cerebellum. The intensity of staining gradually decreased during the second week and finally disappeared. From the 9th postnatal day on, cerebellar Purkinje cells expressed strong CA activity, which completely disappeared by the end of the investigation period. CA staining of the oligodendrocytes and pericytes could be observed from the first postnatal day on. The present results raised the possibility that carbonic anhydrase activity may play a role in the regulation of the development and proliferation of some cell types, perhaps via intracellular pH changes.

AB - The postnatal expression of carbonic anhydrase (CA) activity in glia and neurons was investigated by a modified light microscopical method of Hansson. Strong CA activity was observed during the first postnatal week in ameboid microglia, clustering in the cingulum, the periaqueductal region, the roof of the lateral ventricles and the white matter of the cerebellum. The intensity of staining gradually decreased during the second week and finally disappeared. From the 9th postnatal day on, cerebellar Purkinje cells expressed strong CA activity, which completely disappeared by the end of the investigation period. CA staining of the oligodendrocytes and pericytes could be observed from the first postnatal day on. The present results raised the possibility that carbonic anhydrase activity may play a role in the regulation of the development and proliferation of some cell types, perhaps via intracellular pH changes.

UR - http://www.scopus.com/inward/record.url?scp=0025277408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025277408&partnerID=8YFLogxK

U2 - 10.1007/BF00266453

DO - 10.1007/BF00266453

M3 - Article

C2 - 2121672

AN - SCOPUS:0025277408

VL - 94

SP - 441

EP - 447

JO - Histochemie. Histochemistry. Histochimie

JF - Histochemie. Histochemistry. Histochimie

SN - 0948-6143

IS - 4

ER -