Light microscopic and immunohistochemic studies in IgA glomerulonephritis

J. Nagy, H. Brasch, G. Deak

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Abstract

Renal biopsy specimens in 50 cases of IgA glomerulonephritis were studied by light-, immunofluorescent- and occasionally by electron microscopy. Besides a uniform immunohistologic appearance mainly focal or diffuse mesangial proliferative glomerulonephritis was found. In addition to well known glomerular changes, extraglomerular, mostly vascular and interstitial alterations were revealed. In the wall of arteries and arterioles hyalin-like deposits were seen, which by the immunofluorescent method proved to be immunoglobulins and/or C3. Within the interstitium frequently fibrinogen/fibrin was found in addition to a chronic inflammatory reaction and fibrosis detected by light microscopy.

Original languageEnglish
Pages (from-to)99-108
Number of pages10
JournalMorphologiai es Igazsagugyi Orvosi Szemle
Volume22
Issue number2
Publication statusPublished - Jan 1 1982

ASJC Scopus subject areas

  • Medicine(all)

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