The effect of pretreatment with ε-amino-trimethyllysine (TML) 10 mg/kg on the D galactosamine (DGA)-induced hepatitis in mice is described. TML-pretreatment was chosen because experiments have indicated that it elicits processes in the liver similar to those in regeneration and because it has been shown that DGA proved to be ineffective in the newborn or in partially hepatectomized animals, thus on regenerating liver. It was expected that TML pretreatment would protect the animals against the hepatitis inducing effect of DGA. Unexpectedly pretreatment with TML had just the opposite effect, resulting in a severe hemorrhagic hepatitis in several animals. Biochemical and morphologic studies are in progress to elucidate the mechanism of this peculiar effect.
ASJC Scopus subject areas
- Pathology and Forensic Medicine