Light and electron microscopic study of hemorrhagic hepatitis induced by trimethyllysine and d galactosamine

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Abstract

The effect of pretreatment with ε-amino-trimethyllysine (TML) 10 mg/kg on the D galactosamine (DGA)-induced hepatitis in mice is described. TML-pretreatment was chosen because experiments have indicated that it elicits processes in the liver similar to those in regeneration and because it has been shown that DGA proved to be ineffective in the newborn or in partially hepatectomized animals, thus on regenerating liver. It was expected that TML pretreatment would protect the animals against the hepatitis inducing effect of DGA. Unexpectedly pretreatment with TML had just the opposite effect, resulting in a severe hemorrhagic hepatitis in several animals. Biochemical and morphologic studies are in progress to elucidate the mechanism of this peculiar effect.

Original languageEnglish
Pages (from-to)118-129
Number of pages12
JournalExperimental Pathology
Volume13
Issue number2-3
Publication statusPublished - 1977

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Galactosamine
Hepatitis
Electrons
Light
Animals
Liver
Animal Hepatitis
Regeneration
trimethyllysine
Experiments

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

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title = "Light and electron microscopic study of hemorrhagic hepatitis induced by trimethyllysine and d galactosamine",
abstract = "The effect of pretreatment with ε-amino-trimethyllysine (TML) 10 mg/kg on the D galactosamine (DGA)-induced hepatitis in mice is described. TML-pretreatment was chosen because experiments have indicated that it elicits processes in the liver similar to those in regeneration and because it has been shown that DGA proved to be ineffective in the newborn or in partially hepatectomized animals, thus on regenerating liver. It was expected that TML pretreatment would protect the animals against the hepatitis inducing effect of DGA. Unexpectedly pretreatment with TML had just the opposite effect, resulting in a severe hemorrhagic hepatitis in several animals. Biochemical and morphologic studies are in progress to elucidate the mechanism of this peculiar effect.",
author = "A. Tompa and K. Lapis and B. Szende",
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language = "English",
volume = "13",
pages = "118--129",
journal = "Experimental and Toxicologic Pathology",
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T1 - Light and electron microscopic study of hemorrhagic hepatitis induced by trimethyllysine and d galactosamine

AU - Tompa, A.

AU - Lapis, K.

AU - Szende, B.

PY - 1977

Y1 - 1977

N2 - The effect of pretreatment with ε-amino-trimethyllysine (TML) 10 mg/kg on the D galactosamine (DGA)-induced hepatitis in mice is described. TML-pretreatment was chosen because experiments have indicated that it elicits processes in the liver similar to those in regeneration and because it has been shown that DGA proved to be ineffective in the newborn or in partially hepatectomized animals, thus on regenerating liver. It was expected that TML pretreatment would protect the animals against the hepatitis inducing effect of DGA. Unexpectedly pretreatment with TML had just the opposite effect, resulting in a severe hemorrhagic hepatitis in several animals. Biochemical and morphologic studies are in progress to elucidate the mechanism of this peculiar effect.

AB - The effect of pretreatment with ε-amino-trimethyllysine (TML) 10 mg/kg on the D galactosamine (DGA)-induced hepatitis in mice is described. TML-pretreatment was chosen because experiments have indicated that it elicits processes in the liver similar to those in regeneration and because it has been shown that DGA proved to be ineffective in the newborn or in partially hepatectomized animals, thus on regenerating liver. It was expected that TML pretreatment would protect the animals against the hepatitis inducing effect of DGA. Unexpectedly pretreatment with TML had just the opposite effect, resulting in a severe hemorrhagic hepatitis in several animals. Biochemical and morphologic studies are in progress to elucidate the mechanism of this peculiar effect.

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