Light and electron microscopic studies on the medial forebrain bundle in rat: III. Degenerated nerve elements in the medial hypothalamic nuclei following surgical transections of the medial forebrain bundle

Hoang Van Cuc, Csaba Léránth, M. Palkóvits

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Transections of the rat medial forebrain bundle at various levels and the separation of the medial and lateral hypothalamus were performed to study with light and electron microscopy axonal and terminal degeneration in the arcuate, ventromedial and dorsomedial nuclei and in the median eminence. Fibres entering the MFB from various directions participate in the innervation of the arcuate nucleus. The bulk of extrahypothalamic fibres terminating in the median eminence derive from the lower brain stem and reach their target through the MFB. Preoptic originating and transient fibres also terminate in the median eminence. Following parasagittal separation of the medial and lateral hypothalamus massive degeneration was found in both layers of the median eminence. This is likely to be due to interruption of the supraoptic-hypophyseal tract but axons of intrinsic MFB-neurons might also contribute to the innervation of the median eminence.

Original languageEnglish
Pages (from-to)13-22
Number of pages10
JournalBrain Research Bulletin
Volume5
Issue number1
DOIs
Publication statusPublished - 1980

Fingerprint

Medial Forebrain Bundle
Median Eminence
Electrons
Light
Lateral Hypothalamic Area
Middle Hypothalamus
Arcuate Nucleus of Hypothalamus
Mediodorsal Thalamic Nucleus
Brain Stem
Axons
Electron Microscopy
Neurons

Keywords

  • Medial forebrain bundle Medial hypothalamic nuclei Electron microscope Light microscope Degenerated nerve elements

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Light and electron microscopic studies on the medial forebrain bundle in rat: III. Degenerated nerve elements in the medial hypothalamic nuclei following surgical transections of the medial forebrain bundle",
abstract = "Transections of the rat medial forebrain bundle at various levels and the separation of the medial and lateral hypothalamus were performed to study with light and electron microscopy axonal and terminal degeneration in the arcuate, ventromedial and dorsomedial nuclei and in the median eminence. Fibres entering the MFB from various directions participate in the innervation of the arcuate nucleus. The bulk of extrahypothalamic fibres terminating in the median eminence derive from the lower brain stem and reach their target through the MFB. Preoptic originating and transient fibres also terminate in the median eminence. Following parasagittal separation of the medial and lateral hypothalamus massive degeneration was found in both layers of the median eminence. This is likely to be due to interruption of the supraoptic-hypophyseal tract but axons of intrinsic MFB-neurons might also contribute to the innervation of the median eminence.",
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author = "Cuc, {Hoang Van} and Csaba L{\'e}r{\'a}nth and M. Palk{\'o}vits",
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T2 - III. Degenerated nerve elements in the medial hypothalamic nuclei following surgical transections of the medial forebrain bundle

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AU - Palkóvits, M.

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N2 - Transections of the rat medial forebrain bundle at various levels and the separation of the medial and lateral hypothalamus were performed to study with light and electron microscopy axonal and terminal degeneration in the arcuate, ventromedial and dorsomedial nuclei and in the median eminence. Fibres entering the MFB from various directions participate in the innervation of the arcuate nucleus. The bulk of extrahypothalamic fibres terminating in the median eminence derive from the lower brain stem and reach their target through the MFB. Preoptic originating and transient fibres also terminate in the median eminence. Following parasagittal separation of the medial and lateral hypothalamus massive degeneration was found in both layers of the median eminence. This is likely to be due to interruption of the supraoptic-hypophyseal tract but axons of intrinsic MFB-neurons might also contribute to the innervation of the median eminence.

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