An antiserum raised to synthetic adrenocorticotrophin (ACTH) was bound to large neurons of the cerebellar nuclei in rat. In these neurons, the matrix microtubules of the cell bodies and dendritic processes were ACTH-positive. In the axon terminals, 40 nm diameter clear synaptic vesicles were stained in both the deep cerebellar nuclei and red nucleus. Following transection of the superior cerebellar peduncle, ACTH-labeled terminals disappeared in the red nucleus, suggesting that the ACTH-labeled neurons were projection neurons of the cerebellar nuclei.
ASJC Scopus subject areas