Ligands for the central benzodiazepine receptor: Structure-affinity relationship studies on imidazo[1,2-b]pyridazines

Péter Mátyus, Gordon B. Barling, Peter W. Harrison, Margaret G. Wong, Les P. Davies

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9 Citations (Scopus)

Abstract

Seventy-six imidazo[1,2-b]pyridazines and some bicyclic isomers have been analysed and compared in terms of geometric and electronic requirements for binding to central benzodiazepine receptors. The binding sites identified for these compounds by molecular modelling are consistent with known benzodiazepine receptor-ligand interaction models. However, for the most active compounds, additional binding sites are proposed.

Original languageEnglish
Pages (from-to)435-442
Number of pages8
JournalAustralian Journal of Chemistry
Volume49
Issue number4
Publication statusPublished - Dec 1 1996

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ASJC Scopus subject areas

  • Chemistry(all)

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