Lifetime exposure to arsenic in residential drinking water in Central Europe

Rupert Lloyd Hough, Tony Fletcher, Giovanni Sebastiano Leonardi, Walter Goessler, Patrizia Gnagnarella, Felicity Clemens, Eugen Gurzau, Kvetoslava Koppova, Peter Rudnai, Rajiv Kumar, Marie Vahter

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective Methods and results are presented for an arsenic exposure assessment integral to an epidemiological case-control study of arsenic and cancer-the European Commission funded ASHRAM (Arsenic Health Risk Assessment and Molecular Epidemiology) study carried out in some counties of Hungary, Romania and Slovakia. Methods The exposure history of each participant (N = 1,392) was constructed by taking into account how much water they consumed (as water, in drinks and in food), sources of drinking water in their various residences over their lifetime, and the concentrations of arsenic in their various water supplies measured by Hydride Generation-Atomic Absorption Spectrometry (HG-AAS). Concentrations of arsenic in previous water supplies were either derived from contemporary analyses of the same source, or from routine historical data from measurements performed by the authorities in each country. Using this approach, 80% of the recorded lifetime residential history was matched to an arsenic concentration. Seven indices of current, life time, and peak exposure were calculated. Results The exposure indices were all log-normally distributed and the mean and median lifetime average concentrations were in Hungary 14.7 and 13.3 μg l-1, Romania 3.8 and 0.7 μg l-1 and in Slovakia 1.9 and 0.8 μg l-1, respectively. Overall 25% of the population had average concentrations over 10 μg l-1 and 8% with exposure over 50 μg l-1. Conclusions Careful assessment of arsenic in drinking water supplies (both current and previous) enabled the majority of study participants' cumulative lifetime of potential exposure to arsenic in residential water to be characterised.

Original languageEnglish
Pages (from-to)471-481
Number of pages11
JournalInternational Archives of Occupational and Environmental Health
Volume83
Issue number5
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Arsenic
Drinking Water
Water Supply
Romania
Slovakia
Hungary
Water
Molecular Epidemiology
Case-Control Studies
Spectrum Analysis
History
Food
Health
Population

Keywords

  • Arsenic
  • Case-control study
  • Drinking water
  • Exposure assessment
  • Food frequency questionnaire
  • HG-AAS
  • Population study

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Hough, R. L., Fletcher, T., Leonardi, G. S., Goessler, W., Gnagnarella, P., Clemens, F., ... Vahter, M. (2010). Lifetime exposure to arsenic in residential drinking water in Central Europe. International Archives of Occupational and Environmental Health, 83(5), 471-481. https://doi.org/10.1007/s00420-010-0519-1

Lifetime exposure to arsenic in residential drinking water in Central Europe. / Hough, Rupert Lloyd; Fletcher, Tony; Leonardi, Giovanni Sebastiano; Goessler, Walter; Gnagnarella, Patrizia; Clemens, Felicity; Gurzau, Eugen; Koppova, Kvetoslava; Rudnai, Peter; Kumar, Rajiv; Vahter, Marie.

In: International Archives of Occupational and Environmental Health, Vol. 83, No. 5, 06.2010, p. 471-481.

Research output: Contribution to journalArticle

Hough, RL, Fletcher, T, Leonardi, GS, Goessler, W, Gnagnarella, P, Clemens, F, Gurzau, E, Koppova, K, Rudnai, P, Kumar, R & Vahter, M 2010, 'Lifetime exposure to arsenic in residential drinking water in Central Europe', International Archives of Occupational and Environmental Health, vol. 83, no. 5, pp. 471-481. https://doi.org/10.1007/s00420-010-0519-1
Hough, Rupert Lloyd ; Fletcher, Tony ; Leonardi, Giovanni Sebastiano ; Goessler, Walter ; Gnagnarella, Patrizia ; Clemens, Felicity ; Gurzau, Eugen ; Koppova, Kvetoslava ; Rudnai, Peter ; Kumar, Rajiv ; Vahter, Marie. / Lifetime exposure to arsenic in residential drinking water in Central Europe. In: International Archives of Occupational and Environmental Health. 2010 ; Vol. 83, No. 5. pp. 471-481.
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abstract = "Objective Methods and results are presented for an arsenic exposure assessment integral to an epidemiological case-control study of arsenic and cancer-the European Commission funded ASHRAM (Arsenic Health Risk Assessment and Molecular Epidemiology) study carried out in some counties of Hungary, Romania and Slovakia. Methods The exposure history of each participant (N = 1,392) was constructed by taking into account how much water they consumed (as water, in drinks and in food), sources of drinking water in their various residences over their lifetime, and the concentrations of arsenic in their various water supplies measured by Hydride Generation-Atomic Absorption Spectrometry (HG-AAS). Concentrations of arsenic in previous water supplies were either derived from contemporary analyses of the same source, or from routine historical data from measurements performed by the authorities in each country. Using this approach, 80{\%} of the recorded lifetime residential history was matched to an arsenic concentration. Seven indices of current, life time, and peak exposure were calculated. Results The exposure indices were all log-normally distributed and the mean and median lifetime average concentrations were in Hungary 14.7 and 13.3 μg l-1, Romania 3.8 and 0.7 μg l-1 and in Slovakia 1.9 and 0.8 μg l-1, respectively. Overall 25{\%} of the population had average concentrations over 10 μg l-1 and 8{\%} with exposure over 50 μg l-1. Conclusions Careful assessment of arsenic in drinking water supplies (both current and previous) enabled the majority of study participants' cumulative lifetime of potential exposure to arsenic in residential water to be characterised.",
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N2 - Objective Methods and results are presented for an arsenic exposure assessment integral to an epidemiological case-control study of arsenic and cancer-the European Commission funded ASHRAM (Arsenic Health Risk Assessment and Molecular Epidemiology) study carried out in some counties of Hungary, Romania and Slovakia. Methods The exposure history of each participant (N = 1,392) was constructed by taking into account how much water they consumed (as water, in drinks and in food), sources of drinking water in their various residences over their lifetime, and the concentrations of arsenic in their various water supplies measured by Hydride Generation-Atomic Absorption Spectrometry (HG-AAS). Concentrations of arsenic in previous water supplies were either derived from contemporary analyses of the same source, or from routine historical data from measurements performed by the authorities in each country. Using this approach, 80% of the recorded lifetime residential history was matched to an arsenic concentration. Seven indices of current, life time, and peak exposure were calculated. Results The exposure indices were all log-normally distributed and the mean and median lifetime average concentrations were in Hungary 14.7 and 13.3 μg l-1, Romania 3.8 and 0.7 μg l-1 and in Slovakia 1.9 and 0.8 μg l-1, respectively. Overall 25% of the population had average concentrations over 10 μg l-1 and 8% with exposure over 50 μg l-1. Conclusions Careful assessment of arsenic in drinking water supplies (both current and previous) enabled the majority of study participants' cumulative lifetime of potential exposure to arsenic in residential water to be characterised.

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